Since the discovery of enzyme-like activity of Fe3O4 nanoparticles in 2007,nanozymes are becoming the promising substitutes for natural enzymes due to their advantages of high catalytic activity,low cost,mild reaction...Since the discovery of enzyme-like activity of Fe3O4 nanoparticles in 2007,nanozymes are becoming the promising substitutes for natural enzymes due to their advantages of high catalytic activity,low cost,mild reaction conditions,good stability,and suitable for large-scale production.Recently,with the cross fusion of nanomedicine and nanocatalysis,nanozyme-based theranostic strategies attract great attention,since the enzymatic reactions can be triggered in the tumor microenvironment to achieve good curative effect with substrate specificity and low side effects.Thus,various nanozymes have been developed and used for tumor therapy.In this review,more than 270 research articles are discussed systematically to present progress in the past five years.First,the discovery and development of nanozymes are summarized.Second,classification and catalytic mechanism of nanozymes are discussed.Third,activity prediction and rational design of nanozymes are focused by highlighting the methods of density functional theory,machine learning,biomimetic and chemical design.Then,synergistic theranostic strategy of nanozymes are introduced.Finally,current challenges and future prospects of nanozymes used for tumor theranostic are outlined,including selectivity,biosafety,repeatability and stability,in-depth catalytic mechanism,predicting and evaluating activities.展开更多
In this paper,the mechatronic design and maneuverability analysis of a novel robotic shark are presented.To obtain good maneuverability,a barycenter regulating device is designed to assist the posture adjustment at lo...In this paper,the mechatronic design and maneuverability analysis of a novel robotic shark are presented.To obtain good maneuverability,a barycenter regulating device is designed to assist the posture adjustment at low speeds.Based on the Newton-Euler approach,an analytical dynamic model is established with particular consideration of pectoral fins for threedimensional motions.The hydrodynamic coefficients are computed using computational fluid dynamics(CFD)methods.Oscillation amplitudes and phases are determined by fitting an optimized fish body wave.The performance of the robotic shark is estimated by varying the oscillation frequency and offset angle.The results show that with oscillation frequency increasing,the swimming speed increases linearly.The robotic shark reaches the maximum swimming speed of 1.05 m/s with an oscillation frequency of 1.2 Hz.Furthermore,the turning radius decreases nonlinearly as the offset angle increased.The robotic shark reaches the minimum turning radius of 1.4 times the body length with 0.2 Hz frequency and 12°offset angle.In the vertical plane,as the pectoral fin angle increases,the diving velocity increases nonlinearly with increase rate slowing down.展开更多
A review is provided of various approaches that have been adopted recently to assess the fatigue of ships and offshore structures.The relevant fatigue loading is reviewed first,focusing on the successive loading and u...A review is provided of various approaches that have been adopted recently to assess the fatigue of ships and offshore structures.The relevant fatigue loading is reviewed first,focusing on the successive loading and unloading of the cargo and the transient loadings.The factors influencing fatigue strength are discussed,including the geometrical parameters,material,residual stress,and ones related to the environment.Different approaches for fatigue analyses of seam-welded joints are covered,i.e.,the structural stress or strain approach,the notch stress or strain approach,notch intensity approach,and the crack propagation approach.展开更多
The Reynolds-averaged Navier–Stokes(RANS)equation was solved using computational fluid dynamics to study the effect of the circulating tank wall on the hydrodynamic coefficient of an autonomous underwater vehicle(AUV...The Reynolds-averaged Navier–Stokes(RANS)equation was solved using computational fluid dynamics to study the effect of the circulating tank wall on the hydrodynamic coefficient of an autonomous underwater vehicle(AUV).Numerical results were compared with the experimental results in the circulating water tank of Harbin Engineering University.The numerical results of the model with different scale ratios under the same water in the flume were studied to investigate the effect of blockage on the hydrodynamic performance of AUV in the circulating flume model test.The results show that the hydrodynamic coefficient is stable with the scale reduction of the model.The influence of blocking effect on AUV is given by combining theoretical calculation with experiment.展开更多
基金S.G.acknowledges the financial support from the National Natural Science Foundation of China(NSFC 52272144,51972076)the Heilongjiang Provincial Natural Science Foundation of China(JQ2022E001)+4 种基金the Natural Science Foundation of Shandong Province(ZR2020ZD42)the Fundamental Research Funds for the Central Universities.H.D.acknowledges the financial support from the National Natural Science Foundation of China(NSFC 22205048)China Postdoctoral Science Foundation(2022M710931 and 2023T160154)Heilongjiang Postdoctoral Science Foundation(LBH-Z22010)G.Y.acknowledges the financial support from the National Science Foundation of Heilongjiang Education Department(324022075).
文摘Since the discovery of enzyme-like activity of Fe3O4 nanoparticles in 2007,nanozymes are becoming the promising substitutes for natural enzymes due to their advantages of high catalytic activity,low cost,mild reaction conditions,good stability,and suitable for large-scale production.Recently,with the cross fusion of nanomedicine and nanocatalysis,nanozyme-based theranostic strategies attract great attention,since the enzymatic reactions can be triggered in the tumor microenvironment to achieve good curative effect with substrate specificity and low side effects.Thus,various nanozymes have been developed and used for tumor therapy.In this review,more than 270 research articles are discussed systematically to present progress in the past five years.First,the discovery and development of nanozymes are summarized.Second,classification and catalytic mechanism of nanozymes are discussed.Third,activity prediction and rational design of nanozymes are focused by highlighting the methods of density functional theory,machine learning,biomimetic and chemical design.Then,synergistic theranostic strategy of nanozymes are introduced.Finally,current challenges and future prospects of nanozymes used for tumor theranostic are outlined,including selectivity,biosafety,repeatability and stability,in-depth catalytic mechanism,predicting and evaluating activities.
基金financially supported by the National Natural Science Foundation of China(Grant No.51909040)the Natural Science Foundation of Heilongjiang Province(Grant No.LH2020E073)the Key Technology Research and Development Program of Shandong(Grant No.2020CXGC010702).
文摘In this paper,the mechatronic design and maneuverability analysis of a novel robotic shark are presented.To obtain good maneuverability,a barycenter regulating device is designed to assist the posture adjustment at low speeds.Based on the Newton-Euler approach,an analytical dynamic model is established with particular consideration of pectoral fins for threedimensional motions.The hydrodynamic coefficients are computed using computational fluid dynamics(CFD)methods.Oscillation amplitudes and phases are determined by fitting an optimized fish body wave.The performance of the robotic shark is estimated by varying the oscillation frequency and offset angle.The results show that with oscillation frequency increasing,the swimming speed increases linearly.The robotic shark reaches the maximum swimming speed of 1.05 m/s with an oscillation frequency of 1.2 Hz.Furthermore,the turning radius decreases nonlinearly as the offset angle increased.The robotic shark reaches the minimum turning radius of 1.4 times the body length with 0.2 Hz frequency and 12°offset angle.In the vertical plane,as the pectoral fin angle increases,the diving velocity increases nonlinearly with increase rate slowing down.
文摘A review is provided of various approaches that have been adopted recently to assess the fatigue of ships and offshore structures.The relevant fatigue loading is reviewed first,focusing on the successive loading and unloading of the cargo and the transient loadings.The factors influencing fatigue strength are discussed,including the geometrical parameters,material,residual stress,and ones related to the environment.Different approaches for fatigue analyses of seam-welded joints are covered,i.e.,the structural stress or strain approach,the notch stress or strain approach,notch intensity approach,and the crack propagation approach.
基金Supported by the National Natural Science Foundation of China(Grant No.51909040)the Fund of Science and Technology on Underwater Vehicle Technology(Grant No.JCKYS2022SXJQR-11)+1 种基金the Heilongjiang Provincial Natural Science Foundation of China(Grant No.LH2020E073)the Key Technology Research and Development Program of Shandong(Grant No.2020CXGC010702).
文摘The Reynolds-averaged Navier–Stokes(RANS)equation was solved using computational fluid dynamics to study the effect of the circulating tank wall on the hydrodynamic coefficient of an autonomous underwater vehicle(AUV).Numerical results were compared with the experimental results in the circulating water tank of Harbin Engineering University.The numerical results of the model with different scale ratios under the same water in the flume were studied to investigate the effect of blockage on the hydrodynamic performance of AUV in the circulating flume model test.The results show that the hydrodynamic coefficient is stable with the scale reduction of the model.The influence of blocking effect on AUV is given by combining theoretical calculation with experiment.
