High-efficiency seawater electrolysis is impeded by the low activity and low durability of oxygen evolution catalysts due to the complex composition and competitive side reactions in seawater.Herein,a heterogeneousstr...High-efficiency seawater electrolysis is impeded by the low activity and low durability of oxygen evolution catalysts due to the complex composition and competitive side reactions in seawater.Herein,a heterogeneousstructured catalyst is constructed by depositing NiFe-layered double hydroxides(NiFe-LDH)on the substrate of MXene(V_(2)CT_(x))modified Ni foam(NF),and abbreviated as NiFe-LDH/V_(2)CT_(x)/NF.As demonstrated,owing to the intrinsic negative charge characteristic of V_(2)CT_(x),chlorine ions are denied entry to the interface between NiFeLDH and V_(2)CT_(x)/NF substrate,thus endowing NiFe-LDH/V_(2)CT_(x)/NF catalyst with high corrosion resistance and durable stability for 110 h at 500 mA cm^(-2).Meanwhile,the two-dimensional structure and high electrical conductivity of V_(2)CT_(x) can respectively enlarge the electrochemical active surface area and guarantee fast charge transfer,thereby synergistically promoting the catalytic performance of NiFe-LDH/V_(2)CT_(x)/NF in both deionized water electrolyte(261 m V at 100 m A cm^(-2))and simulated seawater electrolyte(241 mV at 100 mA cm^(-2)).This work can guide the preparation of oxygen evolution catalysts and accelerate the industrialization of seawater electrolysis.展开更多
A novel pitch determination algorithm with binary lateral inhibition network (BLIN) is proposed in this paper. A thread like spectrum, which is composed of the fundamental frequency and its harmonic components, is a...A novel pitch determination algorithm with binary lateral inhibition network (BLIN) is proposed in this paper. A thread like spectrum, which is composed of the fundamental frequency and its harmonic components, is acquired by applying a BLIN to the short time spectrum of the speech signal. Then the pitch is determined by the average interval of harmonics. The algorithm is evaluated on COSDIC speech database. For comparison, the same results obtained from the same speech sample with the cepstrum and autocorrelation based pitch determination algorithms are also presented. The results show that the new algorithm is superior to the cepstrum and autocorrelation based pitch determination algorithms.展开更多
The additive manufacturing(AM)of Ni-based superalloys has attracted extensive interest from both academia and industry due to its unique capabilities to fabricate complex and high-performance components for use in hig...The additive manufacturing(AM)of Ni-based superalloys has attracted extensive interest from both academia and industry due to its unique capabilities to fabricate complex and high-performance components for use in high-end industrial systems.However,the intense temperature gradient induced by the rapid heating and cooling processes of AM can generate high levels of residual stress and metastable chemical and structural states,inevitably leading to severe metallurgical defects in Ni-based superalloys.Cracks are the greatest threat to these materials’integrity as they can rapidly propagate and thereby cause sudden and non-predictable failure.Consequently,there is a need for a deeper understanding of residual stress and cracking mechanisms in additively manufactured Ni-based superalloys and ways to potentially prevent cracking,as this knowledge will enable the wider application of these unique materials.To this end,this paper comprehensively reviews the residual stress and the various mechanisms of crack formation in Ni-based superalloys during AM.In addition,several common methods for inhibiting crack formation are presented to assist the research community to develop methods for the fabrication of crack-free additively manufactured components.展开更多
Autophagy is closely related to the drug resistance and metastasis in cancer therapy.Nanoparticlemediated co-delivery of combinatorial therapy with small-molecular drugs and nucleic acids is promising to address drug ...Autophagy is closely related to the drug resistance and metastasis in cancer therapy.Nanoparticlemediated co-delivery of combinatorial therapy with small-molecular drugs and nucleic acids is promising to address drug resistance.Here,a drug-delivering-drug(DDD)platform consisting of anti-tumor-drug nanorods as a vehicle for cytosol delivery of nucleic acid(miR-101)with potent autophagic-inhibition activity is reported for combinatorial therapy.The developed 180-nm nanoplatform,with total drug loading of up to 66%,delivers miR-101 to cancer cells,with threefold increase in intracellular level compared to conventional gene carriers and inhibits the autophagy significantly,along with above twofold reduction in LC3II mRNA and approximately fivefold increase in p62 mRNA over the control demonstrated in the results in vivo.And in turn,the delivery of miR-101 potentiates the drug’s ability to kill cancer cells,with a threefold increase in apoptosis over that of chemotherapy alone.The anti-tumor study in vivo indicates the combined therapy that enables a reduction of 80%in tumor volume and>twofold increase in apoptosis than of the single-drug strategy.In summary,via the carrier-free strategy of DDD,this work provides a delivery platform that can be easily customized to overcome drug resistance and facilitates the delivery of combined therapy of small-molecular drugs and nucleic acids.展开更多
The inhibition effect of tert-butyl alcohol(TBA), identified as the·OH radical inhibitor, on the TiO_2 nano assays(TNA) photoelectrocatalytic oxidation of different organics such as glucose and phthalate was repo...The inhibition effect of tert-butyl alcohol(TBA), identified as the·OH radical inhibitor, on the TiO_2 nano assays(TNA) photoelectrocatalytic oxidation of different organics such as glucose and phthalate was reported. The adsorption performance of these organics on the TNA photoelectrode was investigated by using the instantaneous photocurrent value, and the degradation property was examined by using the exhausted reaction. The results showed that glucose exhibited the poor adsorption and easy degradation performance, phthalate showed the strong adsorption and harddegradation, but TBA showed the weak adsorption and was the most difficult to be degraded. The degradation of both glucose and phthalate could be inhibited evidently by TBA. But the effect on glucose was more obvious. The different inhibition effects of TBA on different organics could be attributed to the differences in the adsorption and the degradation property. For instance, phthalate of the strong adsorption property could avoid from the capture of·OH radicals by TBA in TNA photoelectrocatalytic process.展开更多
The corrosion inhibition performance of co-immobilized lysozyme and lipase was investigated in a recirculating cooling water system. Four methods were carried out in co-immobilization, and the operating parameters wer...The corrosion inhibition performance of co-immobilized lysozyme and lipase was investigated in a recirculating cooling water system. Four methods were carried out in co-immobilization, and the operating parameters were optimized by using the respond surface methodology(RSM). The corrosion inhibition performance of co-immobilized lipase and lysozyme was evaluated by weight loss measurements and electrochemical measurements. The results revealed that the optimal co-immobilization method should be the sequential immobilization of lysozyme and then lipase. The inhibition efficiency was 86.10% under the optimal co-immobilized conditions. Electrochemical data showed that co-immobilized lysozyme and lipase was a mixed-type inhibitor and the corrosion inhibition efficiency was 81%.展开更多
Layered double hydroxide(LDH),a kind of 2D layered materials,has been recognized as the promising anticorrosion materials for metal and its alloy.The microstructure,physical/chemical properties,usage in corrosion inhi...Layered double hydroxide(LDH),a kind of 2D layered materials,has been recognized as the promising anticorrosion materials for metal and its alloy.The microstructure,physical/chemical properties,usage in corrosion inhibition and inhibition performance of LDH have been studied separately in open literature.However,there is a lack of a complete review to summarize the status of LDH technology and the potential R&D opportunities in the field of corrosion inhibition.In addition,the challenges for LDH in corrosion inhibition of metal-based system have not been summarized systematically.Herein,we review recent advances in the rational design of LDH for corrosion inhibition of metal-based system(i.e.Mg alloy,Al alloy,steel and concrete)and high-throughput anticorrosion materials development.By evaluating the physical/chemical properties,usage in metal-based system and the corrosion inhibition mechanism of LDH,we highlight several important factors of LDH for anticorrosion performance and common features of LDH in applying different metal alloys.Finally,we provide our perspective and recommendation in this field,including high-throughput techiniques for combinatorial compositional design and rapid synthesis of anticorrosion alloys,with the goal of accelerating the development and application of LDH in corrosion inhibition of metal-based system.展开更多
Mud shale hydration and swelling are major challenges in the development of water-based drilling fuids(WBDFs).In this work,the inhibition performance and inhibition mechanism of polyethylene glycol(PEG)and potassium c...Mud shale hydration and swelling are major challenges in the development of water-based drilling fuids(WBDFs).In this work,the inhibition performance and inhibition mechanism of polyethylene glycol(PEG)and potassium chloride(KCl)were investigated by hot rolling recovery tests,linear swell tests,Fourier transform infrared spectroscopy,X-ray difraction,atomic absorption spectrophotometry and X-ray photoelectron spectroscopy.The experimental results show that the combination of PEG and KCl achieved higher recovery and lower linear swelling rate than those obtained by individual PEG or KCl.Compared to the d-spacing of Na-montmorillonite(Na-Mt)with PEG or KCl,the d-spacing of Na-Mt with PEG+KCl was lower,which indicates that KCl and PEG have synergistic inhibition efect.This synergistic efect can replace sodium ions and water molecules from the interlayer space of Na-Mt and decrease the d-spacing of Na-Mt.Based on the above experimental results and analysis,a method for optimizing PEG and KCl concentrations was proposed and further verifed by rheological and hot rolling recovery tests of WBDFs.Hence,the results of this work can provide valuable theoretical guidance for developing other synergistic inhibitors.展开更多
The design and manufacture of anti-scaling surface is a prospective way to prevent scaling in oil field.In this work,a novel superhydrophobic Cu^(2+)-loaded and DTPMPA-modified anodized copper oxide(S-Cu^(2+)/D-ACO)co...The design and manufacture of anti-scaling surface is a prospective way to prevent scaling in oil field.In this work,a novel superhydrophobic Cu^(2+)-loaded and DTPMPA-modified anodized copper oxide(S-Cu^(2+)/D-ACO)coating was fabricated by modification of 1H,1H,2H,2H-perfluorodecyltriethoxysilane.The valid storing of scale inhibitors at the coating surface and the interfacial release of Cu^(2+)ions contribute to enhancing the anti-scaling of the S-Cu^(2+)/D-ACO coating.The water contact angle of the S-Cu^(2+)/D-ACO coating is 163.03°and exhibits superhydrophobicity,which makes it difficult for CaCO_(3)to deposit at the surface of the coating.DTPMPA will steadily lurk into the inner space,and Cu^(2+)will be loaded at the interface in the form of the DTPMPA:Cu^(2+)chelate.During the deposition of CaCO_(3),the dynamic release of DTPMPA can be realized by transferring DTPMPA:Cu^(2+)to DTPMPA:Ca^(2+).Interestingly,the released Cu^(2+)hinders the active growth of CaCO_(3).After 48 h of scaling,the mass of CaCO_(3)scale at the S-Cu^(2+)/D-ACO coating surface is only 44.1%that of the anodized copper oxide coating.The excellent anti-scaling performance of the S-Cu^(2+)/D-ACO coating is determined by the synergistic effect of the DTPMPA lurking and dynamic release,as well as the Cu^(2+)inhibition at the interface of superhydrophobic coating and against CaCO_(3)deposition.This research provides a new exploration for designing and fabricating anti-scaling superhydrophobic surface for oil field development.展开更多
We studied 14 moderately overweight Typo 2 diabetic patients with essential hypertension in stable metabolic control after a run-in period , and again after 3 months of antihypertensive treatment with the angiotensin-...We studied 14 moderately overweight Typo 2 diabetic patients with essential hypertension in stable metabolic control after a run-in period , and again after 3 months of antihypertensive treatment with the angiotensin-converting enzyme (ACF) inhibitor captopril. Glucose tolerance was tested with a 75g oral glucose load (OGTT) and insulin sensitivity was measured by the insulin suppression test (IST) while dietary and drug treatment of the hyperglycemia was maintained constant. In the whole group. mean blood pressure (MBP) fell progressively over 3months from a baseline value of 123± 3 mmHg (1 mmHg= 0. 133 kpa) to a final value of 115± 2 mmHg(P<0. 005). After treatment, fasting plasma glucose, insulin, free fatty acid (FFA). potassium, and glycosylated hemoglobin concentrations were unchanged from baseline. There were no significant differences in glucose tolerance and insulin sensitivity between pre- and post-trearment values. Neither endogenous (oral glucose) nor exogenous (IST) insulin caused any change in plasma potassium concentration. This resistance to the hypokalemic action of insulin was not affected by captopril.展开更多
Mesoporous SiO_2 microspheres were synthesized using the sol-gel method and were characterized by TEM, FT-IR and BET techniques. The diameter of the microspheres is about 100—150 nm, and the average mesopore diameter...Mesoporous SiO_2 microspheres were synthesized using the sol-gel method and were characterized by TEM, FT-IR and BET techniques. The diameter of the microspheres is about 100—150 nm, and the average mesopore diameter is 2.55 nm, while the specific surface area is 1 088.9 m2/g. Mesoporous SiO_2 microspheres adsorb glutaraldehyde and immobilize laccase by means of the aldehyde group in glutaral which can react with the amidogen of laccase. The immobilization conditions were optimized at a glutaraldehyde concentration of 0.75%, a crosslinking time of 8 h, a laccase concentration of 0.04 L/L and an immobilization time of 10 h. When diesel leakage concentration was 80 mg/L, the highest corrosion inhibition efficiency of immobilized laccase reached 49.23%, which was slightly lower than the corrosion inhibition efficiency of free laccase(59%). The diesel degradation ratio could reach up to 45%. It has been proved that the immobilized laccase could degrade diesel to inhibit corrosion.展开更多
Na211 At and 211 At-Te colloid injections are prepared. It has been demonstrated that the 211 At-Te colloid is stable in vivo and vitro, and can be applied in the study of biology and medicine. In the report, the mode...Na211 At and 211 At-Te colloid injections are prepared. It has been demonstrated that the 211 At-Te colloid is stable in vivo and vitro, and can be applied in the study of biology and medicine. In the report, the model of Murine Ehrlich Ascites Cells cultured in vivo and vitro is elected for a series of experiments. It has been proved that Na 211At and 211At-Te colloid injections possess an inhibition effect on tumor cells. The inhibition effect was expressed in surviving of the mice and inhibiting growth of tumor as well as the changes of enzyme activity. Meanwhile, it was also noticed that Na 211 At and 211 At-Te colloid injections of various dose inhibited the absorb of pyrimidine nucleosides in Murine Ehrlich Ascites Cells. And the effect isn’t reversible. It is closely related to the dose administratered and 50% inhibition rate needs about 1.48×105 Bq/ml culture.展开更多
The effect of 1,25-dihydroxyvitamin D<sub>3</sub> [1,25（OH）<sub>2</sub>D<sub>3</sub>] and13-cis-retinoic acid（RA）on the proliferation of a novel human megakaryoblasticleukemia c...The effect of 1,25-dihydroxyvitamin D<sub>3</sub> [1,25（OH）<sub>2</sub>D<sub>3</sub>] and13-cis-retinoic acid（RA）on the proliferation of a novel human megakaryoblasticleukemia cell line（HIMeg）was investigated.At the concentration of 10<sup>9</sup> 10<sup>6</sup>mol/L,1,25（OH）<sub>2</sub>D<sub>3</sub> and RA showed significant inhibition of the proliferation of themegakaryoblastic leukemic cells,which was demonstrated by the count of survival cells,incorporation of<sup>3</sup>H-TdR and<sup>3</sup>H-UR,and cloning efficiency in dose-dependent and time-dependent manners.The results can further explain the mechanism of differentiation-inducing agents and the effect of 1 ,25（OH）<sub>2</sub>D<sub>3</sub> on myelofibrosis.It is possible for1,25（OH）<sub>2</sub>D<sub>3</sub> and RA to be used to treat malignant megakaryocytic diseases.展开更多
Phospholipase A<sub>2</sub> （PLA<sub>2</sub>） activity in rat serum andhomogenate of liver and lungs was determined by the meth-od of titrating, It was found that scram PLA<sub>2</su...Phospholipase A<sub>2</sub> （PLA<sub>2</sub>） activity in rat serum andhomogenate of liver and lungs was determined by the meth-od of titrating, It was found that scram PLA<sub>2</sub> activity ofadrenalectomized rats （ADX） was 75. 13±7. 94 U, whichwas significantly different from that of control rats （58.88±15. 33U）. When ADX were injected展开更多
The steady-state gain distribution in cladding pumped thulium-doped fiber laser（TDFL） is analytically and numerically solved based on the rate equations including loss coefficients and cross relaxation effect. With ...The steady-state gain distribution in cladding pumped thulium-doped fiber laser（TDFL） is analytically and numerically solved based on the rate equations including loss coefficients and cross relaxation effect. With the gain curve, a problem, which is named optical feedback inhibition（OFI） and always occurs in tandem TDFL-Ho：YAG laser system, is analyzed quantitatively. The actual characteristics of output spectra and power basically prove the conclusion of theoretical analysis. Then a simple mirror-deflected L-shaped cavity is employed to restrain the external feedback and simplify the structure of fiber-bulk Ho：YAG laser. Finally, 25 W of 2097-nm laser power and 51.2% of optical-to-optical conversion efficiency are obtained, and the beam quality factor is less than 1.43 obtained by knife-edge method.展开更多
By analyzing the corrosion of phosphate completion fluid on the P110 steel at 170 °C, the high-temperature corrosion mechanism of phosphate completion fluid was revealed, and a corrosion inhibition method by memb...By analyzing the corrosion of phosphate completion fluid on the P110 steel at 170 °C, the high-temperature corrosion mechanism of phosphate completion fluid was revealed, and a corrosion inhibition method by membrane transformation was proposed and an efficient membrane-forming agent was selected. Scanning electron microscope (SEM) images, X-ray energy spectrum and X-ray diffraction results were used to characterize the microscopic morphology, elemental composition and phase composition of the precipitation membrane on the surface of the test piece. The effect and mechanism of corrosion inhibition by membrane transformation were clarified. The phosphate completion fluid eroded the test piece by high-temperature water vapor and its hydrolyzed products to form a membrane of iron phosphate corrosion product. By changing the corrosion reaction path, the Zn2+ membrane-forming agent could generate KZnPO4 precipitation membrane with high temperature resistance, uniform thickness and tight crystal packing on the surface of the test piece, which could inhibit the corrosion of the test piece, with efficiency up to 69.63%. The Cu2+ membrane-forming agent electrochemically reacted with Fe to precipitate trace elemental Cu on the surface of the test piece, thus forming a protective membrane, which could inhibit metal corrosion, with efficiency up to 96.64%, but the wear resistance was poor. After combining 0.05% Cu2+ and 0.25% Zn2+, a composite protective membrane of KZnPO4 crystal and elemental Cu was formed on the surface of the test piece. The corrosion inhibition efficiency reached 93.03%, which ensured the high corrosion inhibition efficiency and generated a precipitation membrane resistant to temperature and wear.展开更多
Objective To explore the effects of SDS, PBS re-dissolvent solutions on fluorescence values of radioallergosorbent test (RAST) inhibition. Methods Dermatophagoides pterronyssinus allergen immunoCAP and UniCAP 100 Syst...Objective To explore the effects of SDS, PBS re-dissolvent solutions on fluorescence values of radioallergosorbent test (RAST) inhibition. Methods Dermatophagoides pterronyssinus allergen immunoCAP and UniCAP 100 System were used. The Sera Pool consisted of 20 Dermatophagoides pterronyssinus allergic patients sera, their specific IgE fluorescence values were between 12 505 and 24 776. Results Fluorescence value percentages decreased: 62.9%, 54.1%, 43.5%, 6.7%, 3.7%, 2.6%, 2.2%, and 1.4% respectively, when SDS concentrations were at 2%, 1%, 0.5%, 0.25%, 0.1%, 0.05%, 0.025%, and 0.01%. Fluorescence values decreased more than 5% with SDS concentrations equal to 0.25% or higher. PBS in 0.1 and 0.01 mol/L concentrations decreased fluorescence values 2.9% and 0.9% respectively. Conclusions SDS is a commonly used surfactants in allergen extract and re-dissolvent prepared allergen precipitation for RAST inhibition. Thus effects of surfactants (e.g. SDS) upon the RAST inhibition tests must be considered when they were used as re-dissolvent agents to improve protein resolution in RAST inhibition.展开更多
In order to solve the corrosion problem of circulating cooling water system,SA-ZnO@ODA-GO@PU super-hydrophobic coating was synthesized for pipeline protection.After hydrophobic modification,the contact angle(CA)of the...In order to solve the corrosion problem of circulating cooling water system,SA-ZnO@ODA-GO@PU super-hydrophobic coating was synthesized for pipeline protection.After hydrophobic modification,the contact angle(CA)of the coating was above 150°.The antibacterial ability of coating was essential for corrosion protection.SA-ZnO@ODA-GO can seriously damage the cell structure,make the cell content outflow,increase the leakage rate of protein,and make the bacteria unable to reach logarithmic growth phase within 24 h.The corrosion inhibition mechanism analysis of SA-ZnO@ODA-GO@PU coating indicated that the hydrophobic coating as a physical barrier can prevent the water molecules from entering the carbon steel and prevent the surface charge transfer.展开更多
Cadmium ion(Cd^(2+))detection technology plays a prominent role in food safety and human health.Herein,we designed and constructed an 2-aminoethyl dihydrogen phosphate(AEP)@upconversion nanoparticles(UCNPs)fluorescenc...Cadmium ion(Cd^(2+))detection technology plays a prominent role in food safety and human health.Herein,we designed and constructed an 2-aminoethyl dihydrogen phosphate(AEP)@upconversion nanoparticles(UCNPs)fluorescence sensor for quantitative detection of Cd^(2+)in paddy rice based on inner filter effect(IFE)combined with enzyme inhibition mechanism.The AEP modification UCNPs can offer a stable fluorescence donor at 658 nm and be quenched by the oxidized tetramethylbenzidine(oxTMB)catalyzed by horseradish peroxidase(HRP)enzymes.Without addition of Cd^(2+),the fluorescence of AEP@UCNPs fluorescence sensor was weaken due to the IFE between AEP@UCNPs and oxTMB.With addition of Cd^(2+),HRP enzyme activity was inhibited by Cd^(2+),leading to the decreased oxTMB,resulting in the enhance upconversion fluorescence intensity.As a result,the fluorescence intensity signal at 658 nm of the IFE-based AEP@UCNPs fluorescence sensor increased linearly with the increase in Cd^(2+)in a wide range from 0.5μmol/L to 6μmol/L and the limit of detection(LOD)was 24.6 n mol/L.In addition,our proposed IFE-based AEP@UCNPs fluorescence sensor can achieve Cd^(2+)detection in paddy rice in 30 min.展开更多
基金the financial support of the National Natural Science Foundation of China(52162027,52274297 and 52164028)the Hainan Province Science and Technology Special Fund(ZDYF2023SHFZ091)+4 种基金the Hainan Provincial Natural Science Foundation of China(project Nos.221RC540)Hainan Provincial Postdoctoral Science Foundation(project Nos.2022-BH-25)the Collaborative Innovation Center of Marine Science and Technology(Hainan University)the Start-up Research Foundation of Hainan University(KYQD(ZR)2008,23069,23073 and 23067)the specific research fund of The Innovation Platform for Academicians of Hainan Province(YSPTZX202315)。
文摘High-efficiency seawater electrolysis is impeded by the low activity and low durability of oxygen evolution catalysts due to the complex composition and competitive side reactions in seawater.Herein,a heterogeneousstructured catalyst is constructed by depositing NiFe-layered double hydroxides(NiFe-LDH)on the substrate of MXene(V_(2)CT_(x))modified Ni foam(NF),and abbreviated as NiFe-LDH/V_(2)CT_(x)/NF.As demonstrated,owing to the intrinsic negative charge characteristic of V_(2)CT_(x),chlorine ions are denied entry to the interface between NiFeLDH and V_(2)CT_(x)/NF substrate,thus endowing NiFe-LDH/V_(2)CT_(x)/NF catalyst with high corrosion resistance and durable stability for 110 h at 500 mA cm^(-2).Meanwhile,the two-dimensional structure and high electrical conductivity of V_(2)CT_(x) can respectively enlarge the electrochemical active surface area and guarantee fast charge transfer,thereby synergistically promoting the catalytic performance of NiFe-LDH/V_(2)CT_(x)/NF in both deionized water electrolyte(261 m V at 100 m A cm^(-2))and simulated seawater electrolyte(241 mV at 100 mA cm^(-2)).This work can guide the preparation of oxygen evolution catalysts and accelerate the industrialization of seawater electrolysis.
文摘A novel pitch determination algorithm with binary lateral inhibition network (BLIN) is proposed in this paper. A thread like spectrum, which is composed of the fundamental frequency and its harmonic components, is acquired by applying a BLIN to the short time spectrum of the speech signal. Then the pitch is determined by the average interval of harmonics. The algorithm is evaluated on COSDIC speech database. For comparison, the same results obtained from the same speech sample with the cepstrum and autocorrelation based pitch determination algorithms are also presented. The results show that the new algorithm is superior to the cepstrum and autocorrelation based pitch determination algorithms.
基金This work was supported by Shenzhen-Hong Kong Science and Technology Innovation Cooperation Zone Shenzhen Park Project:HZQB-KCZYB-2020030the National Natural Science Foundation of China(No.91860131and No.52074157)+2 种基金Guangdong Provincial Department of Science and Technology,Key-Area Research and Development Program of Guangdong Province(No.2020B090923002)the National Key Research and Development Program of China(No.2017YFB0702901)the Shenzhen Science and Technology Innovation Commission(No.JCYJ20170817111811303,No.KQTD20170328154443162and No.ZDSYS201703031748354).
文摘The additive manufacturing(AM)of Ni-based superalloys has attracted extensive interest from both academia and industry due to its unique capabilities to fabricate complex and high-performance components for use in high-end industrial systems.However,the intense temperature gradient induced by the rapid heating and cooling processes of AM can generate high levels of residual stress and metastable chemical and structural states,inevitably leading to severe metallurgical defects in Ni-based superalloys.Cracks are the greatest threat to these materials’integrity as they can rapidly propagate and thereby cause sudden and non-predictable failure.Consequently,there is a need for a deeper understanding of residual stress and cracking mechanisms in additively manufactured Ni-based superalloys and ways to potentially prevent cracking,as this knowledge will enable the wider application of these unique materials.To this end,this paper comprehensively reviews the residual stress and the various mechanisms of crack formation in Ni-based superalloys during AM.In addition,several common methods for inhibiting crack formation are presented to assist the research community to develop methods for the fabrication of crack-free additively manufactured components.
基金supported by Grants from the National Natural Science Foundation of China(Nos.81872823,81871477)the Ministry of Science and Technology of China(2017ZX09101001-004)+1 种基金the Double First-Class(CPU2018PZQ13)of CPUthe Key Members of the Outstanding Young Teacher of Jiangsu Qing Lan Project(2016).
文摘Autophagy is closely related to the drug resistance and metastasis in cancer therapy.Nanoparticlemediated co-delivery of combinatorial therapy with small-molecular drugs and nucleic acids is promising to address drug resistance.Here,a drug-delivering-drug(DDD)platform consisting of anti-tumor-drug nanorods as a vehicle for cytosol delivery of nucleic acid(miR-101)with potent autophagic-inhibition activity is reported for combinatorial therapy.The developed 180-nm nanoplatform,with total drug loading of up to 66%,delivers miR-101 to cancer cells,with threefold increase in intracellular level compared to conventional gene carriers and inhibits the autophagy significantly,along with above twofold reduction in LC3II mRNA and approximately fivefold increase in p62 mRNA over the control demonstrated in the results in vivo.And in turn,the delivery of miR-101 potentiates the drug’s ability to kill cancer cells,with a threefold increase in apoptosis over that of chemotherapy alone.The anti-tumor study in vivo indicates the combined therapy that enables a reduction of 80%in tumor volume and>twofold increase in apoptosis than of the single-drug strategy.In summary,via the carrier-free strategy of DDD,this work provides a delivery platform that can be easily customized to overcome drug resistance and facilitates the delivery of combined therapy of small-molecular drugs and nucleic acids.
基金the National High Technology Research and Development Program of China (Grant No.2009AA063003)the National Nature Science Foundation of China (No.20677039) for financial support
文摘The inhibition effect of tert-butyl alcohol(TBA), identified as the·OH radical inhibitor, on the TiO_2 nano assays(TNA) photoelectrocatalytic oxidation of different organics such as glucose and phthalate was reported. The adsorption performance of these organics on the TNA photoelectrode was investigated by using the instantaneous photocurrent value, and the degradation property was examined by using the exhausted reaction. The results showed that glucose exhibited the poor adsorption and easy degradation performance, phthalate showed the strong adsorption and harddegradation, but TBA showed the weak adsorption and was the most difficult to be degraded. The degradation of both glucose and phthalate could be inhibited evidently by TBA. But the effect on glucose was more obvious. The different inhibition effects of TBA on different organics could be attributed to the differences in the adsorption and the degradation property. For instance, phthalate of the strong adsorption property could avoid from the capture of·OH radicals by TBA in TNA photoelectrocatalytic process.
基金financially supported by the National Natural Science Foundation of China (project 21077133)the Natural Foundation of Shandong Province and the Top Talent Project of China University of Petroleum (16RC17040003)
文摘The corrosion inhibition performance of co-immobilized lysozyme and lipase was investigated in a recirculating cooling water system. Four methods were carried out in co-immobilization, and the operating parameters were optimized by using the respond surface methodology(RSM). The corrosion inhibition performance of co-immobilized lipase and lysozyme was evaluated by weight loss measurements and electrochemical measurements. The results revealed that the optimal co-immobilization method should be the sequential immobilization of lysozyme and then lipase. The inhibition efficiency was 86.10% under the optimal co-immobilized conditions. Electrochemical data showed that co-immobilized lysozyme and lipase was a mixed-type inhibitor and the corrosion inhibition efficiency was 81%.
基金the Graduate Research and innovation of Chongqing,China(Grant No.CYB20005)the project of Technological Innovation and Application Development in Chongqing(cstc2019jscxmsxm0378)+8 种基金the National Natural Science Foundation of China(Grant Nos.51908092)the Joint Funds of the National Natural Science Foundation of China-Guangdong(Grant No.U1801254)the project funded by Chongqing Special Postdoctoral Science Foundation(XmT2018043)Natural Science Foundation Project of Chongqing for Post-doctor(cstc2019jcyjbsh0079)Technological projects of Chongqing Municipal Education Commission(KJZDK201800801)Projects(No.2020CDJXZ001,2020CDCGJ006 and 2020CDCGCL004)the Fundamental Research Funds for the Central Universitiesthe Innovative Research Team of Chongqing(CXTDG201602014)the Innovative technology of New materials and metallurgy(2019CDXYCL0031).
文摘Layered double hydroxide(LDH),a kind of 2D layered materials,has been recognized as the promising anticorrosion materials for metal and its alloy.The microstructure,physical/chemical properties,usage in corrosion inhibition and inhibition performance of LDH have been studied separately in open literature.However,there is a lack of a complete review to summarize the status of LDH technology and the potential R&D opportunities in the field of corrosion inhibition.In addition,the challenges for LDH in corrosion inhibition of metal-based system have not been summarized systematically.Herein,we review recent advances in the rational design of LDH for corrosion inhibition of metal-based system(i.e.Mg alloy,Al alloy,steel and concrete)and high-throughput anticorrosion materials development.By evaluating the physical/chemical properties,usage in metal-based system and the corrosion inhibition mechanism of LDH,we highlight several important factors of LDH for anticorrosion performance and common features of LDH in applying different metal alloys.Finally,we provide our perspective and recommendation in this field,including high-throughput techiniques for combinatorial compositional design and rapid synthesis of anticorrosion alloys,with the goal of accelerating the development and application of LDH in corrosion inhibition of metal-based system.
基金This work was financially supported by the Natural Science Foundation of China(51974270)Innovation Union of China National Petroleum Corporation and Southwest Petroleum University(2020CX040102,2020CX040201)Open Fund(PLN201814)of the State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation(Southwest Petroleum University).
文摘Mud shale hydration and swelling are major challenges in the development of water-based drilling fuids(WBDFs).In this work,the inhibition performance and inhibition mechanism of polyethylene glycol(PEG)and potassium chloride(KCl)were investigated by hot rolling recovery tests,linear swell tests,Fourier transform infrared spectroscopy,X-ray difraction,atomic absorption spectrophotometry and X-ray photoelectron spectroscopy.The experimental results show that the combination of PEG and KCl achieved higher recovery and lower linear swelling rate than those obtained by individual PEG or KCl.Compared to the d-spacing of Na-montmorillonite(Na-Mt)with PEG or KCl,the d-spacing of Na-Mt with PEG+KCl was lower,which indicates that KCl and PEG have synergistic inhibition efect.This synergistic efect can replace sodium ions and water molecules from the interlayer space of Na-Mt and decrease the d-spacing of Na-Mt.Based on the above experimental results and analysis,a method for optimizing PEG and KCl concentrations was proposed and further verifed by rheological and hot rolling recovery tests of WBDFs.Hence,the results of this work can provide valuable theoretical guidance for developing other synergistic inhibitors.
基金financially supported by the National Science Foundation for Distinguished Young Scholars of China(Grant No.51925403)the Major Research Plan of National Natural Science Foundation of China(Grant No.91934302)the National Science Foundation of China(21676052,21606042)
文摘The design and manufacture of anti-scaling surface is a prospective way to prevent scaling in oil field.In this work,a novel superhydrophobic Cu^(2+)-loaded and DTPMPA-modified anodized copper oxide(S-Cu^(2+)/D-ACO)coating was fabricated by modification of 1H,1H,2H,2H-perfluorodecyltriethoxysilane.The valid storing of scale inhibitors at the coating surface and the interfacial release of Cu^(2+)ions contribute to enhancing the anti-scaling of the S-Cu^(2+)/D-ACO coating.The water contact angle of the S-Cu^(2+)/D-ACO coating is 163.03°and exhibits superhydrophobicity,which makes it difficult for CaCO_(3)to deposit at the surface of the coating.DTPMPA will steadily lurk into the inner space,and Cu^(2+)will be loaded at the interface in the form of the DTPMPA:Cu^(2+)chelate.During the deposition of CaCO_(3),the dynamic release of DTPMPA can be realized by transferring DTPMPA:Cu^(2+)to DTPMPA:Ca^(2+).Interestingly,the released Cu^(2+)hinders the active growth of CaCO_(3).After 48 h of scaling,the mass of CaCO_(3)scale at the S-Cu^(2+)/D-ACO coating surface is only 44.1%that of the anodized copper oxide coating.The excellent anti-scaling performance of the S-Cu^(2+)/D-ACO coating is determined by the synergistic effect of the DTPMPA lurking and dynamic release,as well as the Cu^(2+)inhibition at the interface of superhydrophobic coating and against CaCO_(3)deposition.This research provides a new exploration for designing and fabricating anti-scaling superhydrophobic surface for oil field development.
文摘We studied 14 moderately overweight Typo 2 diabetic patients with essential hypertension in stable metabolic control after a run-in period , and again after 3 months of antihypertensive treatment with the angiotensin-converting enzyme (ACF) inhibitor captopril. Glucose tolerance was tested with a 75g oral glucose load (OGTT) and insulin sensitivity was measured by the insulin suppression test (IST) while dietary and drug treatment of the hyperglycemia was maintained constant. In the whole group. mean blood pressure (MBP) fell progressively over 3months from a baseline value of 123± 3 mmHg (1 mmHg= 0. 133 kpa) to a final value of 115± 2 mmHg(P<0. 005). After treatment, fasting plasma glucose, insulin, free fatty acid (FFA). potassium, and glycosylated hemoglobin concentrations were unchanged from baseline. There were no significant differences in glucose tolerance and insulin sensitivity between pre- and post-trearment values. Neither endogenous (oral glucose) nor exogenous (IST) insulin caused any change in plasma potassium concentration. This resistance to the hypokalemic action of insulin was not affected by captopril.
基金supported by the Foundation for Top Talents Program of China University of Petroleum
文摘Mesoporous SiO_2 microspheres were synthesized using the sol-gel method and were characterized by TEM, FT-IR and BET techniques. The diameter of the microspheres is about 100—150 nm, and the average mesopore diameter is 2.55 nm, while the specific surface area is 1 088.9 m2/g. Mesoporous SiO_2 microspheres adsorb glutaraldehyde and immobilize laccase by means of the aldehyde group in glutaral which can react with the amidogen of laccase. The immobilization conditions were optimized at a glutaraldehyde concentration of 0.75%, a crosslinking time of 8 h, a laccase concentration of 0.04 L/L and an immobilization time of 10 h. When diesel leakage concentration was 80 mg/L, the highest corrosion inhibition efficiency of immobilized laccase reached 49.23%, which was slightly lower than the corrosion inhibition efficiency of free laccase(59%). The diesel degradation ratio could reach up to 45%. It has been proved that the immobilized laccase could degrade diesel to inhibit corrosion.
文摘Na211 At and 211 At-Te colloid injections are prepared. It has been demonstrated that the 211 At-Te colloid is stable in vivo and vitro, and can be applied in the study of biology and medicine. In the report, the model of Murine Ehrlich Ascites Cells cultured in vivo and vitro is elected for a series of experiments. It has been proved that Na 211At and 211At-Te colloid injections possess an inhibition effect on tumor cells. The inhibition effect was expressed in surviving of the mice and inhibiting growth of tumor as well as the changes of enzyme activity. Meanwhile, it was also noticed that Na 211 At and 211 At-Te colloid injections of various dose inhibited the absorb of pyrimidine nucleosides in Murine Ehrlich Ascites Cells. And the effect isn’t reversible. It is closely related to the dose administratered and 50% inhibition rate needs about 1.48×105 Bq/ml culture.
文摘The effect of 1,25-dihydroxyvitamin D<sub>3</sub> [1,25（OH）<sub>2</sub>D<sub>3</sub>] and13-cis-retinoic acid（RA）on the proliferation of a novel human megakaryoblasticleukemia cell line（HIMeg）was investigated.At the concentration of 10<sup>9</sup> 10<sup>6</sup>mol/L,1,25（OH）<sub>2</sub>D<sub>3</sub> and RA showed significant inhibition of the proliferation of themegakaryoblastic leukemic cells,which was demonstrated by the count of survival cells,incorporation of<sup>3</sup>H-TdR and<sup>3</sup>H-UR,and cloning efficiency in dose-dependent and time-dependent manners.The results can further explain the mechanism of differentiation-inducing agents and the effect of 1 ,25（OH）<sub>2</sub>D<sub>3</sub> on myelofibrosis.It is possible for1,25（OH）<sub>2</sub>D<sub>3</sub> and RA to be used to treat malignant megakaryocytic diseases.
文摘Phospholipase A<sub>2</sub> （PLA<sub>2</sub>） activity in rat serum andhomogenate of liver and lungs was determined by the meth-od of titrating, It was found that scram PLA<sub>2</sub> activity ofadrenalectomized rats （ADX） was 75. 13±7. 94 U, whichwas significantly different from that of control rats （58.88±15. 33U）. When ADX were injected
基金Project supported by the National Natural Science Foundation of China(Grant No.61275146)the Research Fund for the Doctoral Program of Higher Education of China(Grant No.20120002110066)the Special Program of the Co-construction with Beijing Municipal Government of China(Grant No.20121000302)
文摘The steady-state gain distribution in cladding pumped thulium-doped fiber laser（TDFL） is analytically and numerically solved based on the rate equations including loss coefficients and cross relaxation effect. With the gain curve, a problem, which is named optical feedback inhibition（OFI） and always occurs in tandem TDFL-Ho：YAG laser system, is analyzed quantitatively. The actual characteristics of output spectra and power basically prove the conclusion of theoretical analysis. Then a simple mirror-deflected L-shaped cavity is employed to restrain the external feedback and simplify the structure of fiber-bulk Ho：YAG laser. Finally, 25 W of 2097-nm laser power and 51.2% of optical-to-optical conversion efficiency are obtained, and the beam quality factor is less than 1.43 obtained by knife-edge method.
基金Supported by the National Natural Science Foundation of China(5215000105)Huo Yingdong Education Foundation(171043).
文摘By analyzing the corrosion of phosphate completion fluid on the P110 steel at 170 °C, the high-temperature corrosion mechanism of phosphate completion fluid was revealed, and a corrosion inhibition method by membrane transformation was proposed and an efficient membrane-forming agent was selected. Scanning electron microscope (SEM) images, X-ray energy spectrum and X-ray diffraction results were used to characterize the microscopic morphology, elemental composition and phase composition of the precipitation membrane on the surface of the test piece. The effect and mechanism of corrosion inhibition by membrane transformation were clarified. The phosphate completion fluid eroded the test piece by high-temperature water vapor and its hydrolyzed products to form a membrane of iron phosphate corrosion product. By changing the corrosion reaction path, the Zn2+ membrane-forming agent could generate KZnPO4 precipitation membrane with high temperature resistance, uniform thickness and tight crystal packing on the surface of the test piece, which could inhibit the corrosion of the test piece, with efficiency up to 69.63%. The Cu2+ membrane-forming agent electrochemically reacted with Fe to precipitate trace elemental Cu on the surface of the test piece, thus forming a protective membrane, which could inhibit metal corrosion, with efficiency up to 96.64%, but the wear resistance was poor. After combining 0.05% Cu2+ and 0.25% Zn2+, a composite protective membrane of KZnPO4 crystal and elemental Cu was formed on the surface of the test piece. The corrosion inhibition efficiency reached 93.03%, which ensured the high corrosion inhibition efficiency and generated a precipitation membrane resistant to temperature and wear.
基金Supported by a grantfrom the Ministryof Science and Technology PRC (2003AA2Z3502 ).
文摘Objective To explore the effects of SDS, PBS re-dissolvent solutions on fluorescence values of radioallergosorbent test (RAST) inhibition. Methods Dermatophagoides pterronyssinus allergen immunoCAP and UniCAP 100 System were used. The Sera Pool consisted of 20 Dermatophagoides pterronyssinus allergic patients sera, their specific IgE fluorescence values were between 12 505 and 24 776. Results Fluorescence value percentages decreased: 62.9%, 54.1%, 43.5%, 6.7%, 3.7%, 2.6%, 2.2%, and 1.4% respectively, when SDS concentrations were at 2%, 1%, 0.5%, 0.25%, 0.1%, 0.05%, 0.025%, and 0.01%. Fluorescence values decreased more than 5% with SDS concentrations equal to 0.25% or higher. PBS in 0.1 and 0.01 mol/L concentrations decreased fluorescence values 2.9% and 0.9% respectively. Conclusions SDS is a commonly used surfactants in allergen extract and re-dissolvent prepared allergen precipitation for RAST inhibition. Thus effects of surfactants (e.g. SDS) upon the RAST inhibition tests must be considered when they were used as re-dissolvent agents to improve protein resolution in RAST inhibition.
基金supported by the CNPC Safety and Environmental Protection Key Technology Research and Promotion Project (2017D-4613)the Sub Project of National Science and Technology Major Project (2016ZX05040-003)
文摘In order to solve the corrosion problem of circulating cooling water system,SA-ZnO@ODA-GO@PU super-hydrophobic coating was synthesized for pipeline protection.After hydrophobic modification,the contact angle(CA)of the coating was above 150°.The antibacterial ability of coating was essential for corrosion protection.SA-ZnO@ODA-GO can seriously damage the cell structure,make the cell content outflow,increase the leakage rate of protein,and make the bacteria unable to reach logarithmic growth phase within 24 h.The corrosion inhibition mechanism analysis of SA-ZnO@ODA-GO@PU coating indicated that the hydrophobic coating as a physical barrier can prevent the water molecules from entering the carbon steel and prevent the surface charge transfer.
基金financially supported by the National Natural Science Foundation of China(32202132,32172229)Young Elite Scientists Sponsorship Program by CAST(2022QNRC001)the Priority Academic Program Development of Jiangsu Higher Educations(PAPD)。
文摘Cadmium ion(Cd^(2+))detection technology plays a prominent role in food safety and human health.Herein,we designed and constructed an 2-aminoethyl dihydrogen phosphate(AEP)@upconversion nanoparticles(UCNPs)fluorescence sensor for quantitative detection of Cd^(2+)in paddy rice based on inner filter effect(IFE)combined with enzyme inhibition mechanism.The AEP modification UCNPs can offer a stable fluorescence donor at 658 nm and be quenched by the oxidized tetramethylbenzidine(oxTMB)catalyzed by horseradish peroxidase(HRP)enzymes.Without addition of Cd^(2+),the fluorescence of AEP@UCNPs fluorescence sensor was weaken due to the IFE between AEP@UCNPs and oxTMB.With addition of Cd^(2+),HRP enzyme activity was inhibited by Cd^(2+),leading to the decreased oxTMB,resulting in the enhance upconversion fluorescence intensity.As a result,the fluorescence intensity signal at 658 nm of the IFE-based AEP@UCNPs fluorescence sensor increased linearly with the increase in Cd^(2+)in a wide range from 0.5μmol/L to 6μmol/L and the limit of detection(LOD)was 24.6 n mol/L.In addition,our proposed IFE-based AEP@UCNPs fluorescence sensor can achieve Cd^(2+)detection in paddy rice in 30 min.
