1文献来源Cho BC,Felip E,Spira AI,et al.Amivantamab plus lazertinib versus osimertinib as first⁃line treatment in patients with EGFR⁃mutated,advanced non⁃small cell lung cancer(NSCLC):primary results from MARIPOSA,a ph...1文献来源Cho BC,Felip E,Spira AI,et al.Amivantamab plus lazertinib versus osimertinib as first⁃line treatment in patients with EGFR⁃mutated,advanced non⁃small cell lung cancer(NSCLC):primary results from MARIPOSA,a phaseⅢ,global,randomized,controlled trial[J].Ann Oncol,2023,34(2S):S1306.展开更多
In the face of increasingly serious environmental pollution,the health of human lung tissues is also facing serious threats.Mogroside IIE(M2E)is the main metabolite of sweetening agents mogrosides from the anti-tussiv...In the face of increasingly serious environmental pollution,the health of human lung tissues is also facing serious threats.Mogroside IIE(M2E)is the main metabolite of sweetening agents mogrosides from the anti-tussive Chinese herbal Siraitia grosvenori.The study elucidated the anti-inflammatory action and molecular mechanism of M2E against acute lung injury(ALI).A lipopolysaccharide(LPS)-induced ALI model was established in mice and MH-S cells were employed to explore the protective mechanism of M2E through the western blotting,co-immunoprecipitation,and quantitative real time-PCR analysis.The results indicated that M2E alleviated LPS-induced lung injury through restraining the activation of secreted phospholipase A2 type IIA(Pla2g2a)-epidermal growth factor receptor(EGFR).The interaction of Pla2g2a and EGFR was identified by co-immunoprecipitation.In addition,M2E protected ALI induced with LPS against inflammatory and damage which were significantly dependent upon the downregulation of AKT and m TOR via the inhibition of Pla2g2a-EGFR.Pla2g2a may represent a potential target for M2E in the improvement of LPS-induced lung injury,which may represent a promising strategy to treat ALI.展开更多
1文献来源研究一:Nakagawa K,Garon EB,Seto T,et al.Ramucirumab plus Erlotinib in patients with untreated,EGFR-mutated,advanced non-small-cell lung cancer(RELAY):A randomised,double-blind,placebo-controlled,phase 3 trial...1文献来源研究一:Nakagawa K,Garon EB,Seto T,et al.Ramucirumab plus Erlotinib in patients with untreated,EGFR-mutated,advanced non-small-cell lung cancer(RELAY):A randomised,double-blind,placebo-controlled,phase 3 trial[J].Lancet Oncol,2019,20(12):1655-1669.研究二:Zhou Q,Wu YL,Cheng Y,et al.CTONG 1509:Phase 3 study of Erlotinib with or without Bevacizumab in untreated Chinese patients with advanced EGFR-mutated NSCLC[J].Ann Oncol,2019,30(5S):v602-v660.2证据水平1b。3背景临床前和临床研究证实厄洛替尼联合抗血管生成药物具有协同作用,可显著延长表皮生长因子受体(epidermal growth factor receptor,EGFR)敏感突变晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的无进展生存期(progression-free survival,PFS)。展开更多
文摘1文献来源Cho BC,Felip E,Spira AI,et al.Amivantamab plus lazertinib versus osimertinib as first⁃line treatment in patients with EGFR⁃mutated,advanced non⁃small cell lung cancer(NSCLC):primary results from MARIPOSA,a phaseⅢ,global,randomized,controlled trial[J].Ann Oncol,2023,34(2S):S1306.
基金the National Natural Science Foundation(81773982,82003937)Youth Academic leaders of the Qinglan Project in Jiangsu province for financial support。
文摘In the face of increasingly serious environmental pollution,the health of human lung tissues is also facing serious threats.Mogroside IIE(M2E)is the main metabolite of sweetening agents mogrosides from the anti-tussive Chinese herbal Siraitia grosvenori.The study elucidated the anti-inflammatory action and molecular mechanism of M2E against acute lung injury(ALI).A lipopolysaccharide(LPS)-induced ALI model was established in mice and MH-S cells were employed to explore the protective mechanism of M2E through the western blotting,co-immunoprecipitation,and quantitative real time-PCR analysis.The results indicated that M2E alleviated LPS-induced lung injury through restraining the activation of secreted phospholipase A2 type IIA(Pla2g2a)-epidermal growth factor receptor(EGFR).The interaction of Pla2g2a and EGFR was identified by co-immunoprecipitation.In addition,M2E protected ALI induced with LPS against inflammatory and damage which were significantly dependent upon the downregulation of AKT and m TOR via the inhibition of Pla2g2a-EGFR.Pla2g2a may represent a potential target for M2E in the improvement of LPS-induced lung injury,which may represent a promising strategy to treat ALI.
文摘1文献来源研究一:Nakagawa K,Garon EB,Seto T,et al.Ramucirumab plus Erlotinib in patients with untreated,EGFR-mutated,advanced non-small-cell lung cancer(RELAY):A randomised,double-blind,placebo-controlled,phase 3 trial[J].Lancet Oncol,2019,20(12):1655-1669.研究二:Zhou Q,Wu YL,Cheng Y,et al.CTONG 1509:Phase 3 study of Erlotinib with or without Bevacizumab in untreated Chinese patients with advanced EGFR-mutated NSCLC[J].Ann Oncol,2019,30(5S):v602-v660.2证据水平1b。3背景临床前和临床研究证实厄洛替尼联合抗血管生成药物具有协同作用,可显著延长表皮生长因子受体(epidermal growth factor receptor,EGFR)敏感突变晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的无进展生存期(progression-free survival,PFS)。
