A flow field around a streamlined body at an intermediate angle of incidence is dominated by cross-flow separation and vortical flow fields. The separated flow leads to a pair of vortices on the leeside of the body; t...A flow field around a streamlined body at an intermediate angle of incidence is dominated by cross-flow separation and vortical flow fields. The separated flow leads to a pair of vortices on the leeside of the body; therefore, it is essential to accurately determine this pair and estimate its size and location. This study utilizes the element-based finite volume method based on RANS equations to compute a 3D axisymmetric flow around a SUBOFF bare submarined hull. Cross-flow vortex structures are then numerically simulated and compared for a submarine with SUBOFF and DRDC STR bows. Computed results of pressure and shear stress distribution on the hull surface and the strength and locations of the vortex structures are presented at an intermediate incidence angle of 20°. A wind tunnel experiment is also conducted to experimentally visualize the vortex structures and measure their core locations. These experimental results are compared with the numerical data, and a good agreement is found.展开更多
Bone remodeling is performed under the joint action of osteoblasts and osteoclasts. Since the effect of osteoclasts has been gradually recognized on bone and joint diseases, targeted researches toward osteoclasts have...Bone remodeling is performed under the joint action of osteoblasts and osteoclasts. Since the effect of osteoclasts has been gradually recognized on bone and joint diseases, targeted researches toward osteoclasts have become a hot research field. This article reviews the relevant medical literature concerning the possible effects of the fluid shear stress (FSS) on the osteoclastogenesis chiefly from the aspects of RANKL-RANK-OPG system, the macrophage colony-stimulating factor (M-CSF), and calcitonin receptor (CTR). On the basis of the changes of the expression of osteoclastic activities, it is suggested that FSS is a potent, important regulator of bone metabolism.展开更多
文摘A flow field around a streamlined body at an intermediate angle of incidence is dominated by cross-flow separation and vortical flow fields. The separated flow leads to a pair of vortices on the leeside of the body; therefore, it is essential to accurately determine this pair and estimate its size and location. This study utilizes the element-based finite volume method based on RANS equations to compute a 3D axisymmetric flow around a SUBOFF bare submarined hull. Cross-flow vortex structures are then numerically simulated and compared for a submarine with SUBOFF and DRDC STR bows. Computed results of pressure and shear stress distribution on the hull surface and the strength and locations of the vortex structures are presented at an intermediate incidence angle of 20°. A wind tunnel experiment is also conducted to experimentally visualize the vortex structures and measure their core locations. These experimental results are compared with the numerical data, and a good agreement is found.
文摘Bone remodeling is performed under the joint action of osteoblasts and osteoclasts. Since the effect of osteoclasts has been gradually recognized on bone and joint diseases, targeted researches toward osteoclasts have become a hot research field. This article reviews the relevant medical literature concerning the possible effects of the fluid shear stress (FSS) on the osteoclastogenesis chiefly from the aspects of RANKL-RANK-OPG system, the macrophage colony-stimulating factor (M-CSF), and calcitonin receptor (CTR). On the basis of the changes of the expression of osteoclastic activities, it is suggested that FSS is a potent, important regulator of bone metabolism.
