摘要
骨关节炎(Osteoarthritis, OA)是一种以关节软骨破坏、滑膜炎症和骨赘形成为特征的慢性退行性关节疾病。OA的发病机制尚未完全阐明,但已知与多种生物学因素密切相关,其中炎症信号通路的激活起到关键作用。以往研究表明,NF-κB信号通路是早期OA炎性信号通路的研究热点。该信号通路不仅调控软骨细胞的退变、凋亡及降解,还能调节关节微环境中的炎性反应。目前,OA尚无有效的治疗方法。现有药物如非甾体抗炎药(NSAIDs)和镇痛药虽能缓解OA症状,但无法阻止疾病进展。蒙医药在控制病情发展方面具有潜在价值。本综述将概述过去五年蒙药润僵汤在OA中的作用机制,探讨其对NF-κB信号通路传导的影响及三者间的相互作用,为蒙药润僵汤的临床应用提供新的见解。
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by destruction of articular cartilage, synovitis, and osteophyte formation. The pathogenesis of OA has not been fully elucidated, but it is known to be closely related to multiple biological factors, among which the activation of inflammatory signaling pathways plays a key role. Previous studies have shown that the NF-κB signaling pathway is a hot research topic in the early inflammatory signaling pathway of osteoarthritis. This signaling pathway not only regulates the degeneration, apoptosis, and degradation of chondrocytes, but also regulates inflammatory responses in the joint microenvironment. At present, there is no effective treatment for OA. Existing drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics can alleviate symptoms of osteoarthritis, but cannot prevent disease progression. Mongolian medicine has potential value in controlling the progression of diseases. This review will provide an overview of the mechanism of action of Mongolian medicine Runjing decoction in OA over the past five years, explore its impact on NF-κB signaling pathway and the interactions between the three, and provide new insights for the clinical application of Mongolian medicine Runjing decoction.
出处
《临床医学进展》
2025年第8期561-569,共9页
Advances in Clinical Medicine
基金
内蒙古自然科学基金2023,项目编号:2023ZD29。
