摘要
目的探讨高压氧(hyperbaric oxygen,HBOT)治疗联合目标导向训练(target-oriented planning,GDT)改善自发性脑出血患儿预后的作用。方法本研究为前瞻性研究。收集2020年1月至2023年12月就诊于湖南省儿童医院康复中心的自发性脑出血患儿临床资料,共30例患儿符合本研究纳入与排除标准,采取随机数字表法将患儿分为两组,每组各15例。一组采取HBOT联合GDT治疗,为HBOT治疗联合GDT组;一组采取常规物理康复治疗,为常规物理康复治疗组。随访12周,收集两组患儿磁共振成像联合磁敏感加权成像(magnetic resonance imaging with susceptibility weighted imaging,MRI-SWI)脑损伤最大横截面、粗大运动功能评估88项(Gross Motor Function Measure 88,GMFM-88)、Berg平衡量表(Berg Balance Scale,BBS)以及日常生活活动能力(Activity of Daily Living,ADL)评分,评估两组康复干预治疗效果。结果协方差分析后的组间比较结果显示,调整治疗前基线值后,HBOT治疗联合GDT组较常规物理康复治疗组治疗后MRI-SWI最大横截面缩小[(3.02±0.12)cm^(2)比(4.77±0.12)cm^(2)],BBS评分增加[(34.294±0.99)分比(27.570±0.99)分],GMFM-88总百分比增加[(65.90±1.19)%比(55.87±1.19)%],ADL评分增加[(58.04±1.14)分比(48.98±1.14)分],以上差异均具有统计学意义(P<0.05)。结论HBOT治疗联合目标导向训练可以改善自发性脑出血患儿脑损伤,促进患儿运动能力以及日常生活能力的恢复。
Objective To explore the effect of hyperbaric oxygen therapy(HBOT)plus target-oriented planning(GDT)on children during the recovery phase of intracerebral hemorrhage(ICH).Methods For this prospective study,30 children with spontaneous ICH were treated at Hunan Children's Hospital between January 2020 and December 2023.Based upon the specific inclusion and exclusion criteria,they were randomized into either HBOT+GDT group(n=15)or conventional physical rehabilitation therapy group(n=15).The relevant outcome measures included maximum cross-sectional area of brain injury assessed by magnetic resonance imaging plus susceptibility weighted imaging(MRI-SWI),Gross Motor Function Measure-88(GMFM-88)score,Berg Balance Scale(BBS)score and Activity of Daily Living(ADL)score.And 12-week follow-ups were conducted for evaluating the intervention effects in both groups.Results After adjusting for baseline values,analysis of covariance(ANCOVA)revealed significant differences between HBOT+GDT and conventional therapy groups post-intervention.HBOT+GDT group demonstrated a significantly lowered MRI-SWI maximum cross-sectional area(2.302±0.12 vs.4.77±0.12 cm^(2)),higher BBS score(34.294±0.99 vs.27.570±0.99),greater GMFM-88 total percentage(65.90%±1.19%vs.55.87%±1.19%)and higher ADL score(58.04±1.14 vs.48.98±1.14).All differences were statistically significant(P<0.05).Conclusions HBOT+GDT may improve brain injury and promote the recovery of motor function and ADL capabilities in children with spontaneous ICH.
作者
段雅琴
张津维
胡继红
刘娟
吴水华
梁大中
Duan Yaqin;Zhang Jinwei;Hu Jihong;Liu Juan;Wu Shuihua;Liang Dazhong(Rehabilitation Center,Children's Hospital(Hunan Children's Hospital),Xiangya School of Medicine,Central South University,Changsha 410007,China;Department of Physical Therapy,Graduate School of Sehan University,Mokpo,Jeollanam-do 58447,Republic of Korea)
出处
《临床小儿外科杂志》
北大核心
2025年第8期752-757,共6页
Journal of Clinical Pediatric Surgery
基金
湖南省中医药科研课题(C2024022)
湖南省自然科学基金面上项目(2025JJ50682)
长沙市科技厅软科学项目(kh2502016)。
关键词
脑出血
自发性
高压氧
目标导向训练
治疗结果
儿童
Cerebral Hemorrhage
Spontaneous Hyperbaric Oxygenation Target-oriented Planning Treatment Outcome Child
作者简介
通信作者:吴水华,Email:292454021@qq.com;通信作者:梁大中(Dae-jung Yang),Email:pt6226@sehan.ac.kr.
