摘要
目的探讨老年脑卒中患者血清神经元特异性烯醇化酶(neuron-specific enolase,NSE)、神经肽Y(neuropeptide Y,NPY)、下丘脑外侧区分泌素(hypocretin,Hcrt)水平变化与睡眠障碍的关系。方法回顾性选取2021年2月至2024年2月南阳市第一人民医院神经内二科接诊的老年脑卒中患者105例,根据匹兹堡睡眠质量指数量表(Pittsburgh sleepquality index,PSQI)评估结果分为睡眠障碍组64例,非睡眠障碍组41例。入院时检测血清NSE、NPY、Hcrt水平,采用PSQI进行睡眠状态评估,比较两组NSE、NPY、Hcrt水平,多因素logistic回归分析老年脑卒中患者发生睡眠障碍的影响因素,并进行ROC曲线分析。结果睡眠障碍组NSE水平显著高于非睡眠障碍组,NPY、Hcrt水平显著低于非睡眠障碍组(P<0.01)。多因素logistic回归分析显示,NSE、NPY、Hcrt、年龄、美国国立卫生研究院卒中量表评分、脑卒中史是老年脑卒中患者发生睡眠障碍的影响因素(P<0.05,P<0.01)。ROC曲线分析显示,NSE、NPY、Hcrt预测老年脑卒中患者发生睡眠障碍的曲线下面积分别为0.797、0.754、0.915。结论血清NSE、NPY、Hcrt与老年脑卒中患者睡眠障碍紧密关联,且对预测睡眠障碍发生有重要价值。
Objective To explore the relationship of changes in serum neuron-specific enolase(NSE),neuropeptide Y(NPY)and hypocretin(Hcrt)levels with sleep disorders in the elderly stroke patients.Methods A total of 105 elderly stroke patients admitted in our department from February 2021 to February 2024 were retrospectively enrolled in this study.According to the results of Pittsburgh sleep quality index(PSQI)evaluation,they were divided into sleep disorder group(64 cases)and non-sleep disorder group(41 cases).The serum NSE,NPY and Hcrt levels at admission were measured,their sleep status was evaluated with PSQI questionnaire,and the levels and clinical data were compared between groups.Multivariate logistic regression analysis was applied to analyze the influencing factors of sleep disorders in elderly stroke patients,and ROC curve analysis was performed.Results The NSE level was significantly higher,and the levels of NPY and Hcrt were obviously lower in the sleep disorder group than the non-sleep disorder group(P<0.01).Multivariate logistic regression analysis suggested that NSE,NPY,Hcrt,age,NIHSS score and history of stroke were independent influencing factor for sleep disorders in elderly stroke patients(P<0.05,P<0.01).ROC curve analysis indicated that the AUC value of NSE,NPY and Hcrt in predicting the occurrence of sleep disorders was 0.797,0.754 and 0.915,respectively.Conclusion Serum NSE,NPY and Hcrt are closely associated with sleep disorders in elderly stroke patients,and are of important value in predicting the occurrence of sleep disorders.
作者
吴芳
刘崇
李菓
Wu Fang;Liu Chong;Li Guo(Second Department of Neurology,Nanyang First People's Hospital,Nanyang 473000,Henan Province,China)
出处
《中华老年心脑血管病杂志》
2025年第10期1372-1375,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
南阳市科技发展计划项目(23KJGG211)。
