摘要
多发性硬化症(MS)的核心特性在于中枢神经系统的炎症性脱髓鞘变化,属于一种自我免疫性的病症,其显著的症状包括在大脑、视神经及脊髓内的髓鞘遭受破裂,并且轴突也会受到影响。目前疾病产生的原因及机理尚不明确,在遗传和环境因素的共同影响下,多种因素相互作用,可能通过自身免疫机制引发疾病。最新研究提示NOD样受体热蛋白结构域相关蛋白3(NLRP3),即NLRP3炎症小体,它的异常激活可能影响MS的发病。鉴于此,笔者通过查阅近十年的相关文献,综述了NLRP3的相关机制以及激活过程、NLRP3与MS间存在的联系,以期为MS的发生发展、相关治疗及作用机制的深入研究提供参考。
Multiple sclerosis(MS)is a complex autoimmune disorder characterized by inflammatory demyelination in the central nervous system.Prominent symptoms include damage to myelin sheaths in the brain,optic nerve,and spinal cord,as well as axonal dysfunction;however,the exact causes and mechanisms of MS remain unclear.Genetic and environmental factors are thought to interact via autoimmune mechanisms,potentially triggering the disease.Recent studies suggest that abnormal activation of the NOD-like receptor thermal protein domain associated protein 3(NLRP3)inflammasome may play a critical role in the pathogenesis of MS.In this context,this review summarizes the molecular mechanisms underlying NLRP3 activation and its connection to MS,considering relevant literature from the past decade.The findings aim to provide insights into the progression of MS and to identify potential therapeutic strategies by elucidating the underlying mechanisms.
作者
黄思华
周哲屹
王硕
钟俊伟
晏洪恩
HUANG Sihua;ZHOU Zheyi;WANG Shuo;ZHONG Junwei;YAN Hongen(Guangxi University of Chinese Medicine,Nanning 530000,China;Department of Neurology,the Third Affiliated Hospital of Guangxi University of Chinese Medicine(Liuzhou Hospital of Traditional Chinese Medicine),Liuzhou 545002)
出处
《中国比较医学杂志》
2025年第8期158-167,共10页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金(82060905)
广西自然科学基金(2023GXNSFAA026431)
柳州市“个十百”人才计划。
作者简介
黄思华(1999-),男,在读硕士研究生,研究方向:中医脑病临床及基础研究。E-mail:hsihua0723@163.com;通信作者:周哲屹(1983-),女,博士,主任医师,研究方向:中西医结合脑病临床及相关研究。E-mail:yingdaizhi@163.com。
