摘要
感音神经性耳聋(sensorineural hearing loss,SNHL)是由内耳感觉毛细胞代谢异常、供血不足、炎症反应等原因导致的听力障碍,严重影响患者的身心健康和工作生活。动脉自旋标记(arterial spin labeling,ASL)作为一种无需使用对比剂的磁共振检查技术,可以在无辐射、无对比剂的情况下,客观反映脑血流灌注和脑血流储备量,在SNHL患者脑血流灌注评估中具有重要价值。ASL技术不仅可以精准定位与SNHL相关功能脑区血流灌注情况,还能动态监测患者治疗前后的脑血流灌注变化,正逐步成为研究SNHL脑血流相关病理生理机制的重要工具。基于此,本文对ASL技术在SNHL患者脑血流灌注评估研究中的新进展进行归纳总结,探讨SNHL患者发生脑血流改变的机制,为临床诊疗和实验室研究提供参考。
Sensorineural hearing loss(SNHL)is a type of hearing impairment caused by metabolic abnormalities of the sensory hair cells in the inner ear,insufficient blood supply,inflammatory reactions,and other factors.It severely affects the patients'physical and mental health,as well as their work and daily life.Arterial spin labeling(ASL),as a contrast-free magnetic resonance imaging technique,can objectively reflect cerebral blood flow perfusion and cerebral blood flow reserve without radiation or contrast agents.It holds significant value in the assessment of cerebral blood flow perfusion in patients with SNHL.ASL can not only precisely locate the blood flow perfusion in brain regions related to SNHL,but also dynamically monitor changes in cerebral blood flow perfusion before and after treatment.It is gradually becoming an important tool for studying the pathophysiological mechanisms of cerebral blood flow in SNHL.Based on this,this article summarizes the latest progress of ASL in the assessment of cerebral blood flow perfusion in patients with SNHL,and explores the mechanisms underlying the changes in cerebral blood flow in these patients,so as to provide some references for clinical diagnosis and treatment as well as laboratory research.
作者
衣泳洁
黄冉冉
王爱杰
黄翘路
李朝蕙
姜兴岳
张国伟
Yi Yongjie;Huang Ranran;Wang Aijie;Huang Qiaolu;Li Chaohui;Jiang Xingyue;Zhang Guowei(School of Medical Imaging,Binzhou Medical University,Yantai 264003,China;Department of Imaging,Yantaishan Hospital,Binzhou Medical University,Yantai 264003,China)
出处
《国际医药卫生导报》
2025年第18期2999-3003,共5页
International Medicine and Health Guidance News
基金
山东省医药卫生科技项目(202409040614)。
关键词
动脉自旋标记
感音神经性耳聋
血流灌注
磁共振成像
进展
Arterial spin labeling
Sensorineural hearing loss
Blood perfusion
Magnetic resonance imaging
Progress
作者简介
通信作者:张国伟,Email:ytszgw@163.com。
