摘要
目的探讨脑机接口结合针刺疗法对脑卒中患者运动、认知功能及日常生活能力恢复的影响。方法采用前瞻性研究方法,选取2023年3月至10月徐州市康复医院康复科收治的40例经确诊为脑卒中患者,根据治疗干预方式将其分为对照组(19例,常规治疗加针刺疗法)和观察组(21例,常规治疗加脑机接口结合针刺疗法),干预前、干预8周采用蒙特利尔认知评估量表(MoCA)、肢体运动功能评分量表(FMA)、日常生活能力量表(Barthel指数)评价两组认知、运动功能及日常生活能力;酶联免疫吸附法检测神经元特异稀醇化酶(NSE)、同型半胱氨酸(Hcy)、S-100β水平;运用超声经颅多普勒血流技术检测大脑前动脉、基底动脉、大脑中动脉的血流速度以及临床疗效。结果干预后,观察组各项FMA、MOCA、Barthel指数评分均高于对照组(P<0.05)。干预后,观察组大脑中动脉血流速度高于对照组[(59.79±9.37)cm/s vs(52.69±8.96)cm/s,t=2.443,P=0.019],血清Hcy、NSE、S-100β水平均低于对照组(P<0.05)。观察组治疗有效率为95.24%,略高于对照组的73.68%,但差异无统计学意义(χ^(2)=2.140,P=0.143)。结论脑机接口结合针刺疗法能明显减轻患者神经功能损伤,恢复血流动力学,改善患者的运动和认知功能。
Objective To investigate the effect of a brain computer interface combined with acupuncture therapy on the recovery of motor function,cognitive function and daily living ability in stroke patients.Methods A prospective study was conducted,enrolling 40 stroke patients diagnosed and treated at the Rehabilitation Department of Xuzhou Rehabilitation Hospital from March to October 2023.According to the treatment intervention method,patients were divided into a control group(19 cases,routine treatment plus acupuncture therapy)and an observation group(21 cases,routine treatment plus brain computer machine interface combined with acupuncture therapy).Before and after 8 weeks of intervention,cognitive function,motor function,and activities of daily living were evaluated using the Montreal Cognitive Assessment(MoCA),the Fugl-Meyer Assessment(FMA),and the Barthel Index,respectively.Neuron-specific enolase(NSE),homocysteine(Hcy),and S-100βlevels were measured using enzyme-linked immuno-sorbent assay(ELISA).Transcranial Doppler ultrasound was used to assess the blood flow velocity in the anterior cerebral artery,basilar artery,and middle cerebral artery,as well as clinical efficacy.Results After intervention,the scores of FMA,MoCA,and Barthel Index in the observation group were significantly higher than those in the control group(P<0.05).After intervention,the blood flow velocity in the middle cerebral artery of the observation group was higher than that of the control group[(59.79±9.37)cm/s vs(52.69±8.96)cm/s,t=2.443,P=0.019],and the serum levels of Hcy,NSE,and S-100βwere lower in the observation group compared to the control group(P<0.05).The effective treatment rate in the observation group was 95.24%,slightly higher than the 73.68%in the control group,but the difference was not statistically significant(χ^(2)=2.140,P=0.143).Conclusion The brain computer interface combined with acupuncture therapy can significantly reduce neurological damage,restore hemodynamics,and improve motor and cognitive function in stroke patients.
作者
陆洁
王平
李洪艳
王金凤
李祥
王春丽
LU Jie;WANG Ping;LI Hongyan;WANG Jinfeng;LI Xiang;WANG Chunli(Xuzhou Medical University,Xuzhou,Jiangsu 221004,China;不详)
出处
《中国临床研究》
2025年第5期725-729,共5页
Chinese Journal of Clinical Research
基金
江苏省卫生健康委员会科研项目(LSD2022010)
徐州市科技重点研发计划项目(KC22216,KC23193)。
关键词
针刺
脑机接口
脑卒中
运动功能
认知功能
血流动力学
Acupuncture
Brain computer interface
Stroke
Motor function
Cognitive function
Hemodynamics
作者简介
通信作者:李洪艳,E-mail:lhysam1017@163.com。
