摘要
牙髓可能由于龋病、外伤等原因导致不可逆的损伤。目前临床针对牙髓炎的治疗方法多为根管治疗,然而根管治疗存在一定的局限性,研究和开发保存牙髓的治疗方案势在必行。表观遗传修饰主要包括DNA甲基化、组蛋白甲基化、组蛋白乙酰化、非编码RNA等,可在不改变遗传基因的情况下调控细胞状态。随着表观遗传学的深入研究,其在牙髓炎症和再生中应用取得了一定突破,本文将就表观遗传修饰在促进牙髓炎症和再生的研究进展作一综述。
The dental pulp may suffer irreversible damage due to reasons such as dental caries and trauma.Currently,most clinical treatments for pulpitis are root canal therapy.However,root canal therapy has certain limitations,and research and development of pulp-preserving treatment options are imperative.Epigenetic modifications,which mainly include DNA methylation,histone methylation,histone acetylation,and non-coding RNAs,can regulate cellular states without altering genes.With the in-depth study of epigenetics,its application in the inflammatory regeneration of dental pulp has made certain breakthroughs.This paper will provide an overview of the research progress on the application of epigenetic modifications in the treatment of dental pulp inflammatory regeneration.
作者
苏芊芊
胡涛
SU Qianqian;HU Tao(State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Frontier Innovation Center for Dental Medicine Plus&Department of Preventive Dentistry,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)
出处
《口腔医学研究》
2025年第4期269-275,共7页
Journal of Oral Science Research
基金
国家自然科学基金区域重点项目(编号:U20A20365)。
关键词
表观遗传
牙髓
炎症
修复
再生
epigenetic
dental pulp
inflammation
repair
regeneration
作者简介
苏芊芊(1999-),女,广东阳江人,硕士在读,研究方向:牙髓损伤修复的表观遗传机制;通信作者:胡涛,E-mail:hutao@scu.edu.cn。
