摘要
目的:探讨富马酸酮替芬分散片联合沙丁胺醇对喘息性支气管炎患儿的影响。方法:回顾性收集2021年6月至2023年12月期间于本院进行治疗的106例喘息性支气管炎患儿的临床资料,根据不同治疗方案分为对照组(n=53,采用沙丁胺醇0.5m雾化吸入治疗,4次·d^(-1))和研究组(n=53,采用富马酸酮替芬分散片0.5 mg,2次·d^(-1)联合沙丁胺醇治疗)。治疗1 w后评价临床疗效、临床症状消失时间;并于治疗1 w后采用肺功能仪检测达峰时间比(Ratio of time to peak tidal expiratory flow to total expiratory time,TPTEF/TE)、呼吸频率(Respiratory rate,RR)、达峰容积比(Ratio of volume to peak tidal expiratory flow to total expiratory volume,VPTEF/VE)和潮气量(Tidal volume,VT),采用酶联免疫吸附法(Enzyme-linked immunosorbent assay,ELISA)检测血清C反应蛋白(C-reactive protein,CRP)、白细胞介素-6(Interleukin-6,IL-6)、半胱氨酰白三烯(Cysteinyl leukotrienes,CysLTs)和白三烯B4(Leukotriene B4,LTB4)水平;并统计治疗期间不良反应发生率。结果:研究组的临床总有效率显著高于对照组(P<0.05)。研究组的发热、咳嗽、喘息、哮鸣音、肺部啰音消失时间均较对照组显著缩短(P<0.05)。治疗后,研究组的TPTEF/TE、VPTEF/VE、VT均显著高于对照组,RR显著低于对照组(P<0.05)。治疗后,研究组的血清CRP、IL-6、CysLTs、LTB4水平均较对照组显著降低(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论:富马酸酮替芬联合沙丁胺醇治疗喘息性支气管炎患儿效果显著,促进临床症状消失,改善肺功能和血清细胞因子。
Objective:To investigate the effects of ketotifen fumarate dispersive tablets combined with salbutamol on children with asthmatic bronchitis.Methods:Clinical data of 106 children with asthmatic bronchitis treated in our hospital from June 2021 to December 2023 were retrospectively collected.They were divided into a control group(n=53,treated with salbutamol 0.5 m nebulization inhalation,4 times·day-1)and a study group(n=53,treated with ketotifen fumarate dispersible tablets 0.5 mg,2 times·day-1 combined with salbutamol).After 1 week of treatment,the clinical efficacy and the time for clinical symptoms to disappear were evaluated,the ratio of time to peak tidal expiratory flow to total expiratory time(TPTEF/TE),respiratory rate(RR),ratio of volume to peak tidal expiratory flow to total expiratory volume(VPTEF/VE),and tidal volume(VT)were measured using a pulmonary function tester.Enzyme-linked immunosorbent assay(ELISA)was used to detect the levels of serum C-reactive protein(CRP),interleukin-6(IL-6),cysteinyl leukotrienes(CysLTs),and leukotriene B4(LTB4),and the incidence of adverse reactions during the treatment period was statistically analyzed.Results:The total clinical effective rate of the study group was significantly higher than that of the control group(P<0.05).The disappearance time of fever,cough,wheeze,wheezing,and lung rale in the study group was significantly shorter than that in the control group(P<0.05).After treatment,the TPTEF/TE,VPTEF/VE,and VT in the study group were significantly higher than those in the control group,and the RR was significantly lower than that in the control group(P<0.05).After treatment,the levels of serum CRP,IL-6,CysLTs,and LTB4 in the study group were significantly lower than those in the control group(P<0.05).There was no significant difference in the overall incidence of adverse reactions between the two groups(P>0.05).Conclusion:The treatment of ketotifen fumarate combined with salbutamol in children with asthmatic bronchitis has significant effects,promoting the disappearance of clinical symptoms,improving lung function and serum cytokines.
作者
陈金荣
Chen Jin-rong(Department of Pediatric Internal Medicine,Shangcai People's Hospital,Zhumadian 463800,Henan,China)
关键词
马酸酮替芬分散片
沙丁胺醇
喘息性支气管炎
Ketotifen fumarate dispersible tablets
Salbutamol
Asthmatic bronchitis
作者简介
陈金荣,女,主任医师,主要从事小儿内科喘息性支气管炎相关治疗,Email:cjr13939656756@163.com。
