摘要
目的探讨屈光参差性近视患者双眼视网膜和脉络膜的结构及血管差异,并进一步探讨其与近视的关系。设计横断面研究。研究对象110名青年近视性屈光参差患者。方法利用相干光断层扫描血管成像技术(OCTA)测量视网膜和脉络膜的厚度、视网膜血管线密度(RVLD)、脉络膜血管体积(CVV)、脉络膜基质体积(CSV)及脉络膜血管指数(CVI)。平均血管宽度和分支点则通过基于OpenCV的自定义Python脚本从OCTA视网膜图像中提取。比较屈光参差患者双眼间视网膜和脉络膜厚度、RVLD、CVV、CSV、CVI、平均血管宽度和血管分支点数的差异。主要指标视网膜和脉络膜厚度、RVLD、CVV、CSV、CVI、平均血管宽度和血管分支点数。结果在大多数区域内,同一个体中近视度数较高眼相比于较低度眼,其视网膜和脉络膜厚度、CVV及CSV均较低。这些测量值随近视度数加深和眼轴延长而降低(P均<0.05)。Logistic回归分析表明,平均血管宽度可能是影响个体屈光差异的显著因素(β=-0.157,P=0.019)。限制性立方样条分析显示,在内环区,当近视程度较低时,CVI随近视程度加深而增加;当近视程度较高,则相反(非线性P<0.05),拐点为-2.112 D。结论在青年屈光参差患者中,随着近视程度增加和眼轴的延长,视网膜和脉络膜厚度变薄、CVV及CSV减少。内环区CVI存在非线性关系,拐点为-2.112 D。平均血管宽度的变化提示其可能在个体屈光参差形成中具有潜在作用。
Objective To investigate the interocular differences in retinal and choroidal morphology and vascularity in patients with anisometropic myopia,and to further explore the relationship with myopia.Design Cross-sectional study.Participants 110 young patients with myopic anisometropia.Methods Using OCTA,measurements were obtained for retinal and choroidal thickness,retinal vessel length density(RVLD),choroidal vessel volume(CVV),choroidal stroma volume(CSV),and choroidal vessel index(CVI).Mean vessel width and branch points were derived from OCTA retinal images using custom Python scripts based on OpenCV.The interocular differences of the retinal and choroidal thickness,RVLD,CVV,CSV,CVI,mean vessel width and branch points were compared.Main Outcome Measures Retinal and choroidal thickness,RVLD,CVV,CSV,CVI,mean vessel width and branch points.Results In most regions,the retinal and choroidal thicknesses,as well as CVV and CSV,were lower in the more myopic eye compared to the less myopic eye.These measurements were correlated with spherical equivalent(SE)and axial length(AL)(all P<0.05).Logistic regression analysis indicated that mean vessel width may be a significant factor influencing the refractive differences between the eyes in individuals(β=-0.157,P=0.019).Restricted cubic spline analysis revealed that in the parafoveal zone,the CVI increased with SE when SE was less than-2.112 D,and decreased when SE was greater(P for nonlinear<0.05).Conclusion In young anisometropic individuals,higher degrees of myopia were associated with thinner retinal and choroidal thicknesses,as well as reduced CVV and CSV,significantly linked to AL and SE.The threshold of the CVI parafoveal was identified at-2.112 D.Variations in mean vessel width suggest potential contributions to individual refractive anisometropia.
作者
杨雨欣
许梦尧
张丰菊
徐玉珊
张琳露
温洁
Yang Yuxin;Xu Mengyao;Zhang Fengju;Xu Yushan;Zhang Linlu;Wen Jie(Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Key Laboratory of Ophthalmology and Visual Science,Beijing 100730,China)
出处
《眼科》
2025年第1期40-46,共7页
Ophthalmology in China
基金
北京市科委科技计划项目(Z201100005520043)。
作者简介
通讯作者:张丰菊,Email:zhangfj126@126.com。
