摘要
目的分析孟鲁司特联合色甘萘甲那敏对过敏性鼻炎患儿免疫球蛋白E(IgE)及Th1/Th2细胞因子水平的影响。方法回顾性分析2020年1月—2022年12月舟山市妇女儿童医院接收的80例过敏性鼻炎患儿临床资料,按照不同治疗方式分为观察组与对照组,每组40例。对照组给予孟鲁司特治疗,观察组给予孟鲁司特联合色甘萘甲那敏治疗。比较两组治疗前后IgE、Th1/Th2细胞因子[白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、干扰素γ(IFN-γ)]水平及临床症状缓解时间、不良反应发生率。结果治疗前,两组IgE、Th1/Th2细胞因子水平比较差异均无统计学意义(均P>0.05);治疗后,两组IgE水平均降低,观察组为(1.12±0.16)IU/L,低于对照组的(1.23±0.22)IU/L,差异有统计学意义(P<0.05),两组Th1/Th2细胞因子水平均改善,观察组IL-4[(35.69±3.14)ng/L]、IL-6[(1.89±0.07)ng/L]水平低于对照组[(37.28±3.47)ng/L、(2.31±0.10)ng/L],IL-2[(7.90±1.59)ng/ml]、IFN-γ[(87.52±9.41)ng/L]水平高于对照组[(6.84±1.33)ng/ml、(83.26±8.75)ng/L],差异均有统计学意义(均P<0.05)。观察组鼻塞、水样鼻涕、阵发性喷嚏症状缓解时间[(3.45±0.86)d、(3.24±0.51)d、(4.12±0.67)d]均短于对照组[(3.93±1.15)d、(4.57±0.68)d、(4.53±0.72)d],差异均有统计学意义(均P<0.05)。观察组不良反应发生率(5.00%)低于对照组(15.00%),差异有统计学意义(P<0.05)。结论孟鲁司特联合色甘萘甲那敏治疗儿童过敏性鼻炎的临床疗效显著,不仅改善IgE及Th1/Th2细胞因子水平,而且加速临床症状缓解,降低不良反应发生风险。
Objective To analyze the effect of montelukast combined with sodium cromoglicate on immunoglobulin E(IgE)and Th1/Th2 cytokines in treatment of children with allergic rhinitis.Methods A retrospective analysis was conducted on the clinical data of 80 children with allergic rhinitis in Zhoushan Women and Children's Hospital from January 2020 to December 2022.The children were divided into observation group and control group according to different treatment methods,with 40 cases in each group.The children in control group were treated with montelukast,while the children in observation group were treated with montelukast combined with sodium cromoglicate.The levels of IgE,Th1/Th2 cytokines[interleukin-2(IL-2),interleukin-4(IL-4),interleukin-6(IL-6),interferonγ(IFN-γ)]before and after treatment,clinical symptom relief time,and incidence rates of adverse reactions were compared between the two groups.Results Before treatment,there was no statistically significant difference in the levels of IgE and Th1/Th2 cytokines between the two groups(P>0.05).After treatment,IgE levels in the two groups decreased,IgE level in observation group was(1.12±0.16)IU/L,which was lower than that in control group[(1.23±0.22)IU/L],there was statistically significant difference(P<0.05),the levels of Th1/Th2 cytokines in the two groups were improved,IL-4 level[(35.69±3.14)ng/L],IL-6 level[(1.89±0.07)ng/L]in observation group were lower than those in control group[(37.28±3.47)ng/L,(2.31±0.10)ng/L],IL-2 level[(7.90±1.59)ng/ml],IFN-γlevel[(87.52±9.41)ng/L]in observation group were higher than those in control group[(6.84±1.33)ng/ml,(83.26±8.75)ng/L],there were statistically significant differences(P<0.05).The relief time of nasal congestion,watery nasal mucus,and paroxysmal sneezing symptoms in observation group[(3.45±0.86)days,(3.24±0.51)days,(4.12±0.67)days]was shorter than that in control group[(3.93±1.15)days,(4.57±0.68)days,(4.53±0.72)days],there were statistically significant differences(P<0.05).The incidence rate of adverse reactions in observation group(5.00%)was lower than that in control group(15.00%),there was statistically significant difference(P<0.05).Conclusion The clinical efficacy of montelukast combined with sodium cromoglicate in treatment of children with allergic rhinitis is significant.It not only significantly optimizes the levels of IgE and Th1/Th2 cytokines,but also accelerates relief of clinical symptoms and reduces the risk of adverse reactions.
作者
贾昕
苏亮
唐识明
董萍
沈玮
姚鹂
姚红
续斌
JIA Xin;SU Liang;TANG Shi-ming;DONG Ping;SHEN Wei;YAO Li;YAO Hong;XU Bin(Department of Otolaryngology,Zhoushan Women and Children's Hospital,Zhoushan,Zhejiang 316000,China;不详)
出处
《中国妇幼保健》
2025年第1期34-37,共4页
Maternal and Child Health Care of China
基金
浙江省舟山市科技计划项目(2021C31097)。
作者简介
通信作者:续斌,E-mail:328516752@qq.com。
