摘要
进行性多灶性脑白质病(PML)是由John Cunningham病毒(JCV)引起的亚急性脱髓鞘脑病,大多数PML患者合并艾滋病,发病后未经治疗的患者预后较差。本综述总结了JCV的感染及发病过程;JCV与免疫细胞及HIV之间的相互作用;结合核磁共振成像、磁敏感加权成像、脑脊液聚合酶链式反应等方法进行早期诊断;目前的治疗方案,包括经典的抗反转录病毒治疗(直接抗病毒治疗和免疫重建治疗),免疫检查点抑制剂,CRISPER/Cas9,T细胞疗法;抗病毒治疗药物开发的阻碍。
Progressive multifocal leukoencephalopathy(PML)is a subacute demyelinating encephalopathy caused by the John Cunningham virus(JCV).PML is most commonly found in patients with AIDS,and the prognosis for untreated patients is poor.This review summarizes the infection and pathogenesis of JCV;the interactions between the JCV virus,immune cells,and HIV;methods for early diagnosis,including magnetic resonance imaging,magnetic susceptibilityweighted imaging,and cerebrospinal fluid polymerase chain reaction;the current therapeutic regimens,such as classical antiretroviral therapy(direct antiviral therapy and immune reconstitution therapy),immune checkpoint inhibitors,CRISPER/Cas9,T cell therapy;and barriers to the development of antiviral drugs.
作者
毛元岱
马萍
MAO Yuandai;MA Ping(Nankai University,Tianjin 300071,China;Tianjin Second People's Hospital,Tianjin 300019,China)
出处
《中国艾滋病性病》
CAS
CSCD
北大核心
2024年第1期89-93,共5页
Chinese Journal of Aids & STD
关键词
进行性多灶性脑白质病
艾滋病病毒
JC病毒
抗病毒治疗
免疫检查点抑制剂
progressive multifocal leukoencephalopathy(PML)
HIV
John Cunningham Virus(JCV)
antiretroviral therapy
immune checkpoint inhibitors
作者简介
第一作者:毛元岱(2000-),女,河南省南阳市人,本科在读,研究方向:临床医学。Email:nkuamao@icloud.com;通信作者:马萍,硕士生导师,Email:mapingtianjin@163.com。
