摘要
目的:探讨盐酸右美托咪定在肝恶性肿瘤微创消融术疼痛中的应用效果。方法:选取2019年3月—2021年10月昆明医科大学第一附属医院收治的行微创消融术的肝恶性肿瘤患者100例为观察对象,根据随机数字表法分为观察组及对照组,各50例。对照组在麻醉前15 min采用盐酸哌替丁和盐酸异丙嗪超前镇痛;观察组在麻醉前15 min采用盐酸右美托咪定前镇痛。比较两组患者生命体征、镇痛情况、苏醒质量、不良反应发生情况。结果:术前和术后24 h,两组患者中心静脉压、心率、血氧饱和度及呼吸比较,差异无统计学意义(P>0.05);观察组术前及术后24 h疼痛评分均低于对照组,差异有统计学意义(P<0.001);两组患者呼吸恢复时间、指令恢复时间、睁眼时间比较,差异无统计学意义(P>0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P=0.029)。结论:肝恶性肿瘤微创消融术患者采用盐酸右美托咪定超前镇痛的镇痛效果良好,安全性高。
Objective:To explore the application effect of dexmedetomidine hydrochloride in minimally invasive ablation pain of hepatic malignant tumors.Methods:One hundred cases of patients with hepatic malignant tumors who underwent minimally invasive ablation admitted to the First Affiliated Hospital of Kunming Medical University from March 2019 to October 2021 were selected as observation subjects,and they were divided into an observation group and a control group,each with fifty cases,according to the method of randomized numerical table.In the control group,pethidine hydrochloride and ipecac hydrochloride were used for hyperalgesia 15 min before anesthesia.The observation group used dexmedetomidine hydrochloride pre-analgesia 15 min before anesthesia.Vital signs,analgesia,quality of awakening,and occurrence of adverse reactions were compared between the two groups.Results:Comparison of central venous pressure,heart rate,oxygen saturation and respiration between the two groups of patients in the preoperative and 24 h postoperative periods showed no statistically significant differences(P>0.05);The pain scores of the observation group were lower than those of the control group in the preoperative and 24 h postoperative periods,and the difference was statistically significant(P<0.001);Comparison of respiratory recovery time,command recovery time and eyes opening time between the two groups,the difference was not statistically significant(P>0.05);The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.029).Conclusion:The analgesic effect of dexmedetomidine hydrochloride preemptive analgesia in patients with minimally invasive ablation of hepatic malignant tumors is good and safe.
作者
张洁
张小梅
Zhang Jie;Zhang Xiaomei(Department of Pain,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,Yunnan Province,China)
出处
《中外医药研究》
2023年第22期24-26,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
肝恶性肿瘤
微创消融术
疼痛
超前镇痛
Hepatic malignant tumor
Minimally invasive ablation
Pain
Preemptive analgesia
