摘要
目的 探讨瑞马唑仑联合环泊酚对老年骨科手术全身麻醉麻醉恢复期认知功能的影响。方法 回顾性选取2022年5月—2023年5月沛县人民医院收治的60例老年骨科手术行全身麻醉的患者的临床资料,根据不同麻醉方案将其分为观察组和对照组,各30例。对照组行一般全身麻醉,观察组采取瑞马唑仑联合环泊酚进行全身麻醉。对比两组患者麻醉前(T1)、麻醉3 min(T2)、麻醉10 min(T3)和苏醒时(T4)的心率(heart rate,HR)和平均动脉压(mean arterial pressure,MAP)、麻醉效果和安全性以及不同麻醉方案对认知功能的影响。结果 与组内T1比较,两组患者在T2、T3时的HR及MAP显著降低,且T2时观察组HR及MAP显著高于对照组,T3时HR高于对照组,差异有统计学意义(P<0.05)。观察组麻醉生效时间、苏醒时间及离室时间均短于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率为3.33%低于对照组,差异有统计学意义(χ~2=5.192,P<0.05)。观察组苏醒后10、30 min的简易精神状态检查表(Mini-Mental State Examination,MMSE)评分显著高于对照组,差异有统计学意义(P<0.05)。结论 瑞马唑仑联合环泊酚用于老年骨科手术全身麻醉,起效快,安全性良好,且对患者的认知功能影响小。
Objective To investigate the effects of remazolam combined with cyclopofol on cognitive function in the elderly patients undergoing general anesthesia during the convalescent period of orthopedic surgery.Methods The clinical data of 60 elderly patients who underwent general anesthesia during orthopedic surgery in Peixian People's Hospital from May 2022 to May 2023 were selected retrospectively.According to different anesthesia schemes,the patients were divided into observation group and control group,with 30 cases in each group.The control group was given general anesthesia,and the observation group was given general anesthesia with remazolam combined with cyclopofol.The heart rate(HR) and mean arterial pressure(MAP) before anesthesia(T1),at 3 min of anesthesia(T2),at 10 min of anesthesia(T3) and after awakening(T4) were compared between the two groups,as well as the anesthesia effects and safety and the effect on their cognitive function of different anesthesia schemes.Results Compared with intra-group T1,HR and MAP of the two groups were significantly reduced at T2 and T3,and the HR and MAP of the observation group at T2 were significantly higher than those of the control group,the HR at T3 was higher than that in control group,and the differences were statistically significant(P<0.05).The effective time of anesthesia,the recovery time and the time of leaving the room in the observation group were shorter than those in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 3.33%,which was lower than that in the control group,and the difference was statistically significant(χ~2=5.192 P<0.05).The Mini-mental State Examination(MMSE) scores of observation group at 10 min and 30 min after awakening were significantly higher than those of control group,and the differences were statistically significant(P<0.05).Conclusion Remazolam combined with cyclopofol for general anesthesia in elderly orthopedic surgery is effective and safe,and has little effect on cognitive function of patients.
作者
邹冲
周灿
张程
ZOU Chong;ZHOU Can;ZHANG Cheng(Department of Anesthesiology,Peixian People's Hospital,Xuzhou,Jiangsu Province,221600 China)
出处
《中外医疗》
2023年第31期106-110,共5页
China & Foreign Medical Treatment
关键词
瑞马唑仑
环泊酚
老年骨科手术
全身麻醉
麻醉恢复期
认知功能
影响
Remazolam
Cyclopofol
Elderly orthopedic surgery
General anesthesia
Anesthesia recovery period
Cognitive function
Influence
作者简介
邹冲(1982-),男,本科,主治医师,研究方向为各种特殊手术及重症病人的麻醉。
