摘要
目的:研究及分析立体定向软通道引流在高血压脑出血患者中的疗效及对创伤应激、脑水肿的影响。方法:选择2016年1月-2020年6月贵州水矿控股集团有限责任公司总医院收治的100例高血压脑出血患者为研究对象,将其根据随机数字表法分为对照组(予以小骨窗清除术治疗)和观察组(予以立体定向软通道引流治疗),每组50例。比较两组临床总有效率、治疗前后的神经损伤指标[神经元特异性烯醇化酶(NSE)、S100B蛋白及胶质纤维酸性蛋白(GFAP)]、创伤应激指标[促肾上腺皮质激素(ACTH)、皮质醇(Cor)、Toll样受体4(TLR4)及肿瘤坏死因子-α(TNF-α)]及脑水肿指标(脑水肿体积及血肿侧扰动系数)。结果:观察组总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗前两组神经损伤指标、创伤应激指标及脑水肿指标比较,差异均无统计学意义(P>0.05);治疗后3、7 d,观察组神经损伤指标、创伤应激指标及脑水肿指标均显著低于对照组,差异均有统计学意义(P<0.05)。结论:立体定向软通道引流在高血压脑出血患者中的疗效较好,且可有效控制创伤应激及脑水肿。
Objective:To study and analyze the effect of stereotactic soft channel drainage in patients with hypertensive cerebral hemorrhage and its influence on traumatic stress and cerebral edema.Method:A total of 100 patients with hypertensive cerebral hemorrhage who were admitted to General Hospital of Guizhou Shuikuang Holding Group Co.,Ltd.from January 2016 to June 2020 were selected as the research subjects,and they were divided into the control group(treated with small bone window removal)and the observation group(treated with stereotactic soft channel drainage)according to the random number table method,with 50 cases in each group.The total clinical effective rate,nerve injury indexes[neuron specific enolase(NSE),S100B protein and glial fibrillary acidic protein(GFAP)],traumatic stress indexes[adrenocorticotropic hormone(ACTH),cortisol(Cor),Toll-like receptor 4(TLR4)and tumor necrosis factor-α(TNF-α)]and cerebral edema indexes(cerebral edema volume and hematoma-side disturbance coefficient)before and after treatment were compared between the two groups.Result:The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in nerve injury indexes,traumatic stress indexes and cerebral edema indexes between the two groups(P>0.05).3 and 7 d after treatment,the indexes of nerve injury,traumatic stress and cerebral edema in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Stereotactic soft channel drainage is effective in patients with hypertensive cerebral hemorrhage,and can effectively control traumatic stress and cerebral edema.
作者
赵思源
张宝平
王国涛
张红广
杜以恩
罗跃贵
ZHAO Siyuan;ZHANG Baoping;WANG Guotao;ZHANG Hongguang;DU Yi’en;LUO Yuegui(General Hospital of Guizhou Shuikuang Holding Group Co.,Ltd.,Liupanshui 553300,China)
出处
《中国医学创新》
CAS
2023年第18期24-27,共4页
Medical Innovation of China
关键词
高血压脑出血
立体定向软通道引流
创伤应激
脑水肿
Hypertensive cerebral hemorrhage
Stereotactic soft channel drainage
Traumatic stress
Cerebral edema
作者简介
通信作者:罗跃贵。
