摘要
目的 探讨不同通量血液透析治疗对慢性肾功能衰竭(CRF)患者甲状旁腺激素(PTH)、碱性磷酸酶(ALP)及钙磷代谢(CPM)的影响。方法 选取2020年5月至2021年10月于重庆市大足区人民医院行血液透析(HD)治疗的CRF患者122例,根据血液透析方法不同分为对照组58例和观察组64例,对照组采用常规低通量血液透析方案进行治疗,观察组采用高通量血液透析方案进行治疗。对比两组血清PTH水平、ALP蛋白表达量、血钙水平、血磷水平和并发症发生状况。结果 治疗后,两组血清PTH水平均有所降低,两组ALP蛋白表达量均有所升高,且观察组血清PTH水平明显低于对照组,ALP蛋白表达量明显高于对照组,差异有统计学意义(P<0.05)。治疗后,两组血钙、血磷水平相比治疗前均有所升高,且观察组血钙、血磷水平高于对照组,差异有统计学意义(P<0.05)。观察组治疗后并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论 相比较低通量HD,高通量HD治疗CRF患者的临床疗效更显著,可有效改善患者肾脏功能,排除体内毒素,提高患者生活质量,降低并发症发生率。
Objective To investigate the effects of different flux hemodialysis treatment on parathyroid hormone(PTH),Alkaline Phosphatase(ALP)and calcium-phosphorus metabolism(CPM)in patients with chronic renal failure(CRF). Methods 122 CRF patients who underwent hemodialysis in Dazu District People’s Hospital of Chongqing from May 2020 to October 2021 were selected,and according to different hemodialysis methods,they were divided into control group of 58 cases and observation group of 64 cases,the control group was treated with conventional low-flux hemodialysis scheme,and the patients in the observation group were treated with the high-flux hemodialysis scheme. The serum PTH level,ALP protein expression,blood calcium level,blood phosphorus level and complications were compared between the two groups.Results After treatment,the serum PTH level in the two groups decreased,and the expression of ALP protein in the two groups increased. The serum PTH level in the observation group was significantly lower than that in the control group,and the expression of ALP protein was significantly higher than that in the control group(P<0.05). After treatment,the levels of blood calcium and blood phosphorus in the two groups were higher than those before treatment,and the levels of blood calcium and blood phosphorus in the observation group were higher than those in the control group(P<0.05). The total incidence of complications in the observation group was lower than that in the control group(P<0.05). Conclusion Compared with low-flux HD,high-flux HD is more effective in the treatment of CRF patients. It can effectively improve the renal function of patients,eliminate toxins in the body,improve the quality of life of patients,and reduce the incidence of complications.
作者
刘晓霞
李仪静
易选维
罗琳
LIU Xiaoxia;LI Yijing;YI Xuanwei;LUO Lin(Department of Hemodialysis,the People's Hospital of Dazu,Chongqing,China,402360)
出处
《分子诊断与治疗杂志》
2023年第1期145-148,共4页
Journal of Molecular Diagnostics and Therapy
基金
重庆市大足区科技发展项目(DZKJ,2018ACC1018)。
作者简介
通信作者:罗琳,E⁃mail:13618278903@163.com。
