摘要
目的探讨p38蛋白表达与结肠癌患者临床病理特征和预后的关系。方法收集2015年6月至2017年6月在西安大兴医院行手术治疗的110例结肠癌患者癌组织及癌旁组织标本。采用免疫组织化学法检测结肠癌组织中p38蛋白表达情况,分析p38蛋白表达与临床病理特征及预后的关系。结果结肠癌组织中p38蛋白阳性表达率为80.9%(89/110),高于癌旁组织的7.3%(8/110),差异有统计学意义(P<0.05)。p38蛋白表达与肿瘤浸润程度、TNM分期、分化程度和淋巴结转移有关(P<0.05)。110例结肠癌患者3年总生存率为60.0%(66/110),3年无复发生存率为49.1%(54/110)。p38蛋白阳性表达患者的总生存率和无复发生存率均低于阴性表达患者,差异均有统计学意义(Log-rankχ^(2)=4.094、4.428,P=0.043、0.035)。多因素Cox比例风险模型分析结果显示:肿瘤TNM分期Ⅲ~Ⅳ期、中/低分化程度、有淋巴结转移和p38蛋白阳性表达是结肠癌患者死亡的独立危险因素(P<0.05);肿瘤最大径>5 cm、浸润程度为侵及浆膜、TNM分期Ⅲ~Ⅳ期、中/低分化程度、有淋巴结转移和p38蛋白阳性表达是结肠癌患者复发的独立危险因素(P<0.05)。结论结肠癌组织中p38蛋白阳性表达,其与肿瘤浸润程度、TNM分期、分化程度及淋巴结转移等临床病理特征及预后有关,可将其作为评估结肠癌患者预后的标志物。
Objective To investigate the relationship between p38 protein expression and clinicopathological features and prognosis of patients with colon cancer.Methods The cancer tissues and paracancerous tissues specimens of 110 patients with colon cancer who underwent surgical treatment in Xi′an Daxing Hospital from June 2015 to June 2017 were collected.The expression of p38 protein in colon cancer tissues was detected by immunohistochemistry,and the relationship between p38 protein expression and clinicopathological features and prognosis was analyzed.Results The positive expression rate of p38 protein in colon cancer tissues was 80.9%(89/110),which was higher than 7.3%(8/110)in paracancerous tissues,and the difference was statistical significance(P<0.05).The expression of p38 protein was associated with degree of tumor infiltration,TNM stage,degree of differentiation and lymph node metastasis(P<0.05).The 3-year overall survival rate of 110 patients with colon cancer was 60.0%(66/110),and the 3-year relapse-free survival rate was 49.1%(54/110).The overall survival rate and the relapse-free survival rate in patients with positive p38 protein expression were lower than those in patients with negative p38 protein expression(Log-rankχ^(2)=4.094 and 4.428,P=0.043 and 0.035).The results of multivariate Cox proportional risk model analysis showed that TNM stageⅢ-Ⅳ,degree of medium/low differentiation,lymph node metastasis and positive expression of p38 protein were independent risk factors for death of colon cancer patients(P<0.05);the maximum diameter of tumor>5 cm,invasion and serous membrane,TNM stageⅢ-Ⅳ,degree of medium/low differentiation,lymph node metastasis and positive expression of p38 protein were independent risk factors for recurrence of colon cancer patients(P<0.05).Conclusion The positive expression of p38 protein in colon cancer tissues is associated with clinicopathological features and prognosis,such as the degree of tumor infiltration,TNM stage,differentiation degree and lymph node metastasis,p38 protein can be used as a marker for evaluating the prognosis of colon cancer patients.
作者
周岳
韩博
ZHOU Yue;HAN Bo(Department of General Surgery,Xi′an Daxing Hospital,Xi?an,Shaanxi 710000,China;Department of Digestive Surgery,Xi′an International Medical Center Hospital,Xi′an,Shaanxi 710100,China)
出处
《检验医学与临床》
CAS
2022年第23期3231-3234,3238,共5页
Laboratory Medicine and Clinic
关键词
结肠癌
P38
临床病理特征
预后
colon cancer
p38
clinicopathological feature
prognosis
作者简介
周岳,男,主治医师,主要从事胃肠道肿瘤方面的研究;通信作者:韩博,E-mail:Hanbss25@yeah.net。
