摘要
目的探讨富血小板纤维蛋白(PRF)在种植体周围炎骨缺损再生中的应用效果。方法选取2019年7—12月本院收治的54例种植体周围炎骨缺损患者作为研究对象,按照随机数字表法分为观察组和对照组,每组27例。对照组给予骨粉联合引导骨再生(GBR)技术治疗,观察组在对照组基础上联合PRF治疗,比较两组术后12个月骨结合成功率、术前及术后6个月成骨情况(骨密度、唇腭向骨厚度、唇腭向骨高度)、术前与术后3个月临床指标(龈沟出血指数、探诊深度、附着丧失)及并发症发生情况。结果术后12个月,观察组骨结合成功率为96.30%,略高于对照组的88.89%,但组间比较差异无统计学意义;术后6个月,两组新骨密度大于术前,唇腭向骨厚度厚于术前,唇腭向骨高度高于术前,且观察组新骨密度大于对照组,唇腭向骨厚度厚于对照组,唇腭向骨高度高于对照组(P<0.05)。术后3个月,两组龈沟出血指数低于术前,探诊深度浅于术前,附着丧失小于术前,且观察组龈沟出血指数低于对照组,探诊深度浅于对照组,附着丧失小于对照组(P<0.05)。术后3个月,观察组并发症发生率(3.70%)略低于对照组(14.81%),但组间比较差异无统计学意义。结论PRF应用于种植体周围炎骨缺损再生中,可明显缓解患者临床症状,抑制骨量丢失,成骨情况较好,可提高骨结合成功率,改善龈沟出血指数,减小附着丧失,降低术后并发症发生率,安全性较高,值得临床推广应用。
Objective To investigate the clinical efficacy of platelet-rich fibrin(PRF)in the regeneration of peri-implantitis bone defects.Methods 54 patients with peri-implantitis and bone defect treated in our hospital from July to December 2019 were selected as the research subjects,and they were divided into the observation group and the control group according to the random number table method,with 27 cases in each group.The control group was treated with bone meal combined with guided bone regeneration(GBR)technology,and the observation group was treated with PRF on the basis of the control group,the success rate of osseointegration was compared at 12 months after surgery,the bone conditions(bone mineral density,thickness of the labial-palatine bone,and height of the labial-palate bone)before surgery and 6 months after surgery,and the clinical indicators(sulcus bleeding index,probing depth,loss of attachment)before surgery and 3 months after surgery and the incident of compliations were compared between the two groups.Results At 12 months after surgery,the success rate of osseointegration in the observation group was 96.30%,which was slightly higher than 88.89%in the control group,but there was no significant difference between the groups;6 months after surgery,the new bone mineral density in the two groups was greater than that before surgery,the thickness of the labial-palatine bone was thicker than that before surgery,and the height of the labial-palate bone was higher than that before surgery,and the new bone density of the observation group was greater than that of the control group,the thickness of the labial-palate bone was thicker than that of the control group,and the the height of the labial-palate bone was higher than that of the control group(P<0.05).At 3 months after surgery,the sulcus bleeding index in the two groups was lower than that before surgery,the probing depth was shallower than that before surgery,and the loss of attachment was smaller than that before surgery,the sulcus bleeding index of the observation group was lower than that of the control group,the probing depth was shallower than that of the control group,and the loss of attachment was less than that of the control group(P<0.05).At 3 months after surgery,the incidence of complications in the observation group(3.70%)was slightly lower than that in the control group(14.81%),but there was no significant difference between the groups.Conclusion The application of PRF in the regeneration of peri-implantitis bone defects can significantly relieve the clinical symptoms of patients,inhibit bone loss,improve osteogenesis,improve the success rate of osseointegration,improve the bleeding index of the gingival sulcus,reduce the loss of attachment and the incidence of postoperative complications,and the safety is high,which is worthy of clinical application.
作者
罗新年
罗心怡
张秋芳
LUO Xinnian;LUO Xinyi;ZHANG Qiufang(Department of Stomatology,Ganzhou People's Hospital,Ganzhou,Jiangxi,341000,China)
出处
《当代医学》
2022年第25期12-16,共5页
Contemporary Medicine
基金
赣州市指导性科技计划(GZ2019ZSF196)。
