摘要
目的观察益气化瘀清热方治疗小儿激素敏感型肾病综合征的疗效。方法2017年7月至2018年7月在河南中医药大学第一附属医院及郑州儿童医院就诊门诊或住院的激素敏感型肾病综合征患儿69例,采用前瞻性队列研究方法,河南中医药大学第一附属医院门诊复查或住院的激素敏感型肾病综合征患儿在西药治疗基础上加用益气化瘀清热方者32例为观察组;郑州儿童医院门诊或住院西药治疗激素敏感型肾病综合征的患儿37例为对照组。对照组采用糖皮质激素治疗,观察组在糖皮质激素治疗基础上加用益气化瘀清热方,观察其在治疗前及治疗后2周、4周、8周、12周及36周的疗效和激素相关副作用。结果疗程足2周时,观察组患儿完全缓解15例,部分缓解17例;对照组完全缓解6例,部分缓解28例,未缓解3例,观察组疗效优于对照组,差异有统计学意义(P=0.008)。36周治疗期间,观察组患儿复发率为12.5%(4/32),显著低于对照组患儿复发率为35.1%(13/37),差异有统计学意义(P=0.048)。观察组患儿感染发生率为31.3%(10/32),低于对照组59.5%(22/37),差异有统计学意义(P=0.029);两组在激素导致的水牛背及满月脸副作用比较差异无统计学意义(P>0.05)。疗程8周后观察组汗出积分和烦躁积分明显低于对照组,差异有统计学意义(P<0.05)。结论益气化瘀清热方具有缩短肾病综合征缓解时间,减少感染次数,降低复发率,减轻激素引起汗出及烦躁。
Objective To observe the curative effect of Yiqi Huayu Qingre decoction on hormone-sensitive nephrotic syndrome in children.Methods A total of 69 outpatients or inpatients with hormone-sensitive nephrotic syndrome treated in the First Affiliated Hospital of Henan University of Chinese Medicine and Zhengzhou Children's Hospital from July 2017 to July 2018 were enrolled in this study.Prospective cohort study was used.The 32 outpatients or inpatients with hormone-sensitive nephrotic syndrome in the First Affiliated Hospital of Henan University of Chinese Medicine were treated with Yiqi Huayu Qingre decoction on the basis of western medicine(observation group),and the 37 children with hormone-sensitive nephrotic syndrome treated with western medicine in outpatient or inpatient department of Zhengzhou Children's Hospital were selected as the control group.The control group was treated with glucocorticoid,and the observation group was treated with Yiqi Huayu Qingre decoction on the basis of glucocorticoid.The efficacy and hormone-related side effects were observed before treatment and 2 weeks,4 weeks,8 weeks,12 weeks and 36 weeks after treatment.Results After 2 weeks of treatment,there were 15 cases of complete remission and 17 cases of partial remission in observation group.In the control group,6 cases were completely relieved,28 cases were partially relieved,and 3 cases were not relieved.The curative effect of the observation group was better than that of the control group,and the difference was statistically significant(P=0.008).During the 36-week treatment,the recurrence rate of the observation group was 12.5%(4/32),which was significantly lower than that of the control group(35.1%,13/37),and the difference was statistically significant(P=0.048).The incidence of infection in the observation group was 31.3%(10/32),which was lower than 59.5%(22/37)in the control group,and the difference was statistically significant(P=0.029).There was no significant difference in buffalo hump or moon face caused by hormones between the two groups(P>0.05).After 8 weeks of treatment,the sweating score and irritability score of the observation group were significantly lower than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Yiqi Huayu Qingre decoction can shorten the remission time of nephrotic syndrome,reduce the number of infections,reduce the recurrence rate,and reduce the sweating and irritability caused by hormones.
作者
高旭光
杨濛
张茂华
翟文生
GAO Xuguang;YANG Meng;ZHANG Maohua;ZHAI Wensheng(The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)
出处
《中国中西医结合儿科学》
2021年第4期358-362,共5页
Chinese Pediatrics of Integrated Traditional and Western Medicine
基金
河南省中医药科学研究专项重点项目(2017ZY1011)
河南省特色学科中医学学科建设项目(15109093-2018)
河南省首批青苗人才培养项目[豫中医科教(2018)16号]。
关键词
肾病综合征
益气化瘀清热方
疗效评价
激素副作用
儿童
Nephrotic syndrome
Yiqi Huayu Qingre decoction
Curative effect evaluation
Hormone-related side effect
Children
作者简介
高旭光(1981-),男,医学硕士,主治医师。研究方向:中医药防治小儿风湿免疫病及肾脏病;通讯作者:翟文生,E-mail:zhaiwensheng0415@126.com。
