摘要
目的观察50%剂量维替泊芬光动力疗法(Photodynamic Therapy,PDT)联合中药治疗黄斑区急性中心性浆液性脉络膜视网膜病变(Central Serous Chorioretinopathy,CSC)的临床疗效。方法回顾性病例研究。2017-01至2019-01在聊城市光明眼科医院确诊为黄斑区急性CSC患者50例50只眼,采用50%剂量PDT联合中药进行治疗,治疗前后,术前及术后2周、4周、12周及半年进行最佳矫正视力(Best Corrected Visual Acuity,BCVA)及光学相干断层扫描(Optical CoherenceTomography,OCT)检查观察治疗的有效性和安全性,BCVA检查采用国际标准视力表进行,并换算为logMAR视力记录。结果治疗后2周、4周、12周及半年最佳矫正视力分别为0.178±0.070、0.064±0.071、0.004±0.079,-0.014±0.060,与治疗前最佳矫正视力0.292±0.104相比差异有统计学意义(P<0.05),治疗后半个月、1、3、6个月视网膜厚度分别为291±36.8,231.9±15.4,222.6±7.5,219.7±5.2,治疗前平均中心凹视网膜厚度476±79.9um相比差异有统计学意义(P<0.05)。平均随访(14.34±3.22)个月,治疗后12个月有1位眼复发,复发率2%,复发者再行50%剂量PDT治疗,复发者治愈,所有患者均未继发脉络膜新生血管。结论50%剂量维替泊芬PDT联合中药治疗黄斑区急性中心性浆液性脉络膜视网膜病变安全有效。
Objective To observe the clinical efficacy of 50%dose of Photodynamic Therapy(PDT)combined with traditional Chinese medicine in the treatment of acute Central Serous Chorioretinopathy(CSC)in the macular area.Methods A retrospective case study was conducted.A total of 50 eyes of 50 patients diagnosed with macular acute CSC who received 50%dose of PDT combined with traditional Chinese medicine in Liaocheng Eye Hospital from January 2017 to January 2019 were included in the study.All patients underwent the Best Corrected Vision Acuity(BCVA),Optical Coherence Tomography(OCT),FFA,ICGA and other examinations.BCVA was performed on an international standard visual acuity chart and converted to LogMAR visual acuity records.Results The average logMAR BCVA was 0.6±0.12,0.8±0.13,0.9±0.14 and 1.0±0.12 at two weeks,four weeks,12 weeks and half a year after the treatment,and the difference was statistically significant compared with that before the treatment(0.5±0.12,P<0.05).The average macular foveal retinal thickness(CMT)was 291±36.8,231.9±15.4,222.6±7.5 and 219.7±5.2 at half a month,one month,three months and six months after the treatment respectively,and the difference was statistically significant compared with that before the treatment(476±79.9 um,P<0.05).The mean follow-up was(14.34±3.22)months.One eye recurred 12 months after treatment,with a recurrence rate of 2%.The relapsed patient was cured after treated with a 50%dose of PDT.Conclusion The 50%dose of PDT combined with Chinese medicine is safe and effective in treating acute CSC in the macular area.
作者
房修岭
张辽
吴建霞
高亚男
FANG Xiuling;ZHANG Liao;WU Jianxia;GAO Yanan(Liaocheng Eye Hospital,Liaocheng 252000,China)
出处
《中华灾害救援医学》
2021年第7期1098-1102,共5页
Chinese Journal of Disaster Medicine
关键词
光动力
中药
中心性浆液性脉络膜视网膜病变
光学相干
photodynamic therapy
Chinese medicine
acute central serous chorioretinopathy
optical coherence
作者简介
通信作者:房修岭,E-mail:lanwoniu1985@126.com。
