摘要
银杏叶提取物(EGb)为原料制成的各种制剂,目前广泛应用于药物、保健食品、功能性饮料等领域。研究表明,EGb具有保护多巴胺能神经元作用,发挥抗帕金森病(PD)的药理活性,具有一定的临床疗效。其作用机制同以下反应有关:与EGb减少脑内氧自由基,增强抗氧化应激能力,抑制多巴胺能神经元凋亡,减弱脑内慢性神经炎症反应,促进神经干细胞增殖,减少应激时兴奋性谷氨酸释放等。本文对近年EGb在治疗PD中的作用机制与临床应用进展进行综述,以期为临床应用EGb治疗PD提供一定的参考依据。
Ginkgo biloba extract(EGb)is used as a raw material in many preparations,and widely used in medicine,health food,functional beverage and other fields.Studies have shown that EGb has protective effects on dopaminergic neurons,exerts anti-Parkinson's disease(PD)pharmacological activities,and has a certain clinical efficacy.Its mechanisms of action are related to EGb reducing oxygen free radicals in brain,enhancing antioxidant stress ability,inhibiting apoptosis of dopaminergic neurons,weakening chronic neuroinflammatory response in brain,promoting proliferation of neural stem cells,and reducing excitatory glutamate release during stress.In this paper,progress on the mechanism and clinical application of EGb in the treatment of PD in recent years has been reviewed,in order to provide some reference for the clinical application of EGb in the treatment of PD.
作者
蒋德旗
毛书慧
JIANG De-Qi;MAO Shu-Hui(School of Biology and Pharmacy,Yulin Normal University,Yulin,Guangxi 537000;Guangxi Key Laboratory of Agricultural Resources Chemistry and Biotechnology,Yulin,Guangxi 537000)
出处
《玉林师范学院学报》
2019年第5期105-109,共5页
Journal of Yulin Normal University
基金
广西自然科学基金项目(2018GXNSFAA050002)。
关键词
银杏叶提取物
帕金森病
多巴胺能神经元
氧化应激
作用机制
Ginkgo biloba extract
Parkinson's disease
dopaminergic neuron
oxidative stress
action mechanism
作者简介
蒋德旗(1986-),男,博士,副研究员,硕士生导师,研究方向:神经药理。
