摘要
目的:评估紫杉醇联合铂类药物对局部晚期宫颈癌(LACC)的近期效果.方法:2017年2月-2019年2月收治LACC患者70例,随机数字表法分为两组各35例.A组选择紫杉醇联合顺铂化疗;B组选择5-氟尿嘧啶联合顺铂化疗.对比两组治疗后近期疗效、最大肿瘤直径变化、药物不良反应.结果:A组缓解率高于B组,治疗后患者ⅠB2期、ⅡA期、ⅡB期最大肿瘤直径较治疗前均有减小,且A组优于B组;A组药物不良反应发生率低于B组,差异均有统计学意义(P<0.05).结论:紫杉醇联合铂类药物治疗LACC,可有效缓解病情进展,减小最大肿瘤直径,且用药不良反应不明显,安全性能较高.
Objective:To explore the short-term effect of paclitaxel combined with platinum drugs on locally advanced cervical cancer.Methods:From February 2017 to February 2019,70 patients with locally advanced cervical cancer were selected,and they were divided into two groups with 35 cases in each group by random number table method.Group A was treated with paclitaxel and cisplatin,group B was treated with 5-fluorouracil and cisplatin.We compared the short-term efficacy,the change of the largest tumor diameter,and adverse drug reactions after treatment between the two groups.Results:The remission rate of group A was higher than that of group B,after treatment,the largest tumor diameter of stageⅠB2,ⅡA andⅡB was smaller than that before treatment,and group A was better than group B,the incidence of adverse drug reactions in group A was lower than that in group B,the difference was statistically significant(P<0.05).Conclusion:Paclitaxel combined with platinum drugs in the treatment of local advanced cervical cancer can effectively alleviate the progress of the disease,reduce the largest tumor diameter,and the adverse reactions were not obvious,the safety performance was high.
作者
郭英
田勍
郑峥
邹长鹏
Guo Ying;Tian Qing;Zheng Zheng;Zou Changpeng(Oncology Department,the First Hospital of Hebei Medical University1,Hebei Shijiazhuang 050031;Thoracic Surgery,the First Hospital of Hebei Medical University2,Hebei Shijiazhuang 050031)
出处
《中国社区医师》
2019年第35期8-9,共2页
Chinese Community Doctors
基金
计划名称：河北省医学科研重点课题
项目名称：金属元素与T细胞亚群对胃癌术后复发转移的影响
项目编号：20180255~~
关键词
紫杉醇
铂类药物
晚期宫颈癌
Paclitaxel
Platinum drugs
Advanced cervical cancer
