摘要
目的寻找帕金森病异动症的独立危险因素,在临床中为合理治疗疾病及降低异动症发生率提供一定的参考依据。方法收集自2017-01-2018-12在郑州大学第一附属医院住院并确诊为帕金森病的149例患者,采用UPDRS IV将患者分为异动症组与无异动症组,详细记录2组患者的一般情况、并发症、病情严重程度、抗帕金森病药物使用概况,通过统计学处理后筛选出异动症的独立危险因素。结果异动症发生率为14.09%;多因素回归分析示异动症独立危险因素为女性(OR=5.506,P=0.011)、LD日均剂量(OR=1.004,P=0.029)、每日LD等效剂量(OR=1.004,P=0.005)、LD每公斤体质量剂量(OR=0.800,P=0.034)。结论女性、较高剂量的LD日均剂量、每日LD等效剂量及LD每公斤体质量剂量与异动症的发生密切相关,临床中针对高危患者应积极进行评估,根据个体特征进行个性化治疗并合理规范的应用左旋多巴类药物则是降低异动症发生、提高患者生活质量的重要决策。
Objective To find out the independent risk factors of dyskinesia in Parkinson’s disease,so as to provide some reference for the reasonable treatment of the disease and the reduction of the incidence of dyskinesia.Methods A total of 149 patients with Parkinson’s disease admitted to our hospital from January 2017 to December 2018 were divided into dyskinesia group and non-dyskinesia group by UPDRS IV.The general condition,complications,severity of illness and use of anti-Parkinson’s disease drugs in the two groups were recorded in detail and the independent risk factors of dyskinesia were screened out by statistical treatment.Results The incidence of dyskinesia was 14.09%.Multivariate regression analysis showed that the independent risk factors for dyskinesia were female(OR=5.506,P = 0.011),average daily dose of LD(OR=1.004,P= 0.029),equivalent dose of LD per day(OR=1.004,P = 0.005),dose of LD per kilogram of body weight(OR=0.800,P=0.034).Conclusion Female,the daily average dose of LD,the equivalent dose of LD and the dose of LD per kilogram of body weight are closely related to the occurrence of dyskinesia.Personalized treatment according to individual characteristics and reasonable and standardized use of levodopa drugs is an important decision to reduce the incidence of dyskinesia and improve the quality of life of patients.
作者
张敏
朱红灿
刘金玲
祝清勇
ZHANG Min;ZHU Hongcan;LIU Jinling;ZHU Qingyong(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中国实用神经疾病杂志》
2019年第22期2472-2478,共7页
Chinese Journal of Practical Nervous Diseases
基金
2020年度河南省高等学校重点科研项目(编号20A310025)
关键词
帕金森病
异动症
左旋多巴
危险因素
Parkinson’s disease
Dyskinesia Levodopa
Risk factors
作者简介
张敏,Email:2568981466@qq.com;通信作者:朱红灿,Email:zhc660407@hotmail.com。
