摘要
目的探讨乙醇灭活非离体瘤段骨重建治疗骨干部恶性骨肿瘤的临床效果。方法选取2016年3月~2018年7月我院收治的62例骨干部恶性骨肿瘤患者作为研究对象,按照随机数字表法分为观察组与对照组,每组各31例。观察组患者给予乙醇灭活非离体瘤段骨重建治疗,对照组患者给予人工假体置换术治疗,观察并评估两组患者的保肢率、死亡率及疾病复发率、卡氏功能状态(KPS)评分、Enneking评分及术后并发症总发生率。结果观察组患者的保肢率高于对照组,差异有统计学意义(P<0.05);观察组患者的死亡率及疾病复发率低于对照组,差异有统计学意义(P<0.05);两组患者治疗前的KPS评分,差异无统计学意义(P>0.05);治疗后,观察组患者的KPS评分高于对照组,差异有统计学意义(P<0.05);两组患者治疗前的Enneking评分比较,差异无统计学意义(P>0.05);治疗后,观察组患者的Enneking评分高于对照组,差异有统计学意义(P<0.05);观察组患者的术后并发症总发生率低于对照组,差异有统计学意义(P<0.05)。结论乙醇灭活非离体瘤段骨重建治疗骨干部恶性骨肿瘤具有较高的临床价值,有利于提高保肢率,并降低死亡率,值得应用及推广。
Objective To investigate the clinical effect of ethanol inactivation of non-in vitro tumor segmental bone reconstruction for the treatment of diaphyseal malignant bone tumor.Methods Sixty-two patients with diaphyseal malignant bone tumor treated in our hospital from March 2016 to July 2018 were selected as the subjects.They were divided into the observation group and control group by random number table method,with 31 cases in each group.The observation group was given ethanol inactivation of non-in vitro tumor segmental bone reconstruction for the treatment,the control group was treated with artificial prosthesis replacement.And the limb salvage rate,mortality and disease recurrence rate,Karnofsky functional status(KPS)score,Enneking score and total postoperative complication rate were observed and evaluated.Results The rate of limb salvage in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The mortality and disease recurrence rate in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in KPS score between the two groups before treatment(P>0.05).After treatment,the KPS score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There was no significant difference in Enneking score between the two groups before treatment(P>0.05).After treatment,the Enneking score of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The total incidence of postoperative complications in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Ethanol inactivation of non-in vitro tumor segmental bone reconstruction has a high clinical value in the treatment of malignant bone tumors of the backbone,which is beneficial to improve limb salvage rate and reduce mortality.It is worthy of application and promotion.
作者
于涵
YU Han(The Second Department of Orthopedics,Anshan Cancer Hospital,Liaoning Province,Anshan 114036,China)
出处
《中国当代医药》
2019年第29期66-68,共3页
China Modern Medicine
关键词
乙醇灭活非离体瘤段骨重建
骨干部恶性骨肿瘤
临床疗效
Ethanol inactivation of non-m vitro tumor segmental bone reconstruction
Diaphyseal malignant bone tumor
Clinical efficacy
