摘要
目的调查结肠癌患者肠道菌群分布情况并分析其临床意义。方法选取2016年1月-2018年1月100例结肠癌患者为结肠癌组,另选取50例健康人群和50例结肠腺瘤作为对照,采用培养法检查粪便菌群分布,并进行比较分析。手术前、后采集结肠癌组患者静脉血,采用ELISA法检测血清D-乳酸、内毒素水平,并与对照组检测结果相比较。结果结肠癌组与对照组进行比较,肠道内粪肠球菌、大肠埃希菌、双歧杆菌、弯曲杆菌和乳酸杆菌活菌集落数存在显著性差异(P<0.05);结肠癌组患者血清D-乳酸、内毒素水平显著高于对照组(P<0.05);与结肠癌患者术前比较,结肠癌患者术后肠道内粪肠球菌、大肠埃希菌、双歧杆菌、弯曲杆菌和乳酸杆菌活菌集落数存在显著性差异(P <0.05),血清D-乳酸和内毒素水平差异均有统计学意义(P<0.05)。结论结肠癌患者容易发生肠道菌群失调,并且以术后更为严重,故肠道菌群的调节可以促进结肠癌的防治。
Objective To investigate the distribution of intestinal flora in patients with colon cancer and analyze its clinical significance. Methods One hundred patients with rectal cancer from January 2016 to January 2018 were enrolled in the colon cancer group, 50 healthy and 50 colon adenoma subjects were selected as controls. The distribution of fecal microbiota was examined by culture method and compared. Venous blood was collected from patients with colon cancer before and after surgery. Serum D-lactate and endotoxin levels were measured by ELISA and compared with the results of the control groups. Results The number of colonies of Escherichia coli, Enterococcus faecalis, Campylobacter, Bifidobacterium,and Lactobacillus in the colon cancer group were significantly different from those in the control group(P<0.05), the levels of serum D-lactate and endotoxin in patients with colon cancer were significantly higher than those in the control group(P<0.05).There were significant differences in the number of colonies of Escherichia coli, Enterococcus faecalis,Campylobacter, Bifidobacterium, and Lactobacillus between patients with colon cancer before and after surgery(P<0.05), as well as there were significant differences in serum D-lactate and endotoxin levels between patients with colon cancer before and after surgery(P<0.05). Conclusion Patients with colon cancer are prone to intestinal flora imbalance, which is more serious in post-operation, so regulating intestinal flora can promote the prevention and treatment of colon cancer.
作者
何花
李建华
杜文志
HE Hua;LI Jianhua;DU Wenzhi(Psychosomatic Health Care Center, the Mental Health Center of Inner Mongolia Autonomous Region, Hohhot Inner Mongolia 010010, China;Medical Department,the Mental Health Center of Inner Mongolia Autonomous Region, Hohhot Inner Mongolia 010010, China)
出处
《中国卫生标准管理》
2019年第11期83-86,共4页
China Health Standard Management
关键词
结肠癌
肠道菌群
菌群失调
分布
临床意义
分析
colon cancer
intestinal flora
dysbacteriosis
distribution
clinical significance
analysis
作者简介
通信作者:杜文志.
