摘要
目的探讨富马酸喹硫平治疗阿尔茨海默病(AD)患者精神行为症状疗效与安全性。方法 AD患者74例,随机分为治疗组48例和对照组26例。对照组给予盐酸多奈哌齐,起始剂量5 mg,每天1次,连续治疗12周。治疗组在对照组治疗基础上,给予富马酸喹硫平,起始剂量12.5 mg,每天1次。分别于治疗前(基线),治疗1,2,4,8和12周末采用简易精神状态检查量表(MMSE)、简明精神病评定量表(BPRS)、神经精神科问卷(NPI)、NPI苦恼因子和日常生活能力量表(ADL)进行评估。结果治疗1周,治疗组与对照组的NPI总分分别为(72.830±10.45)和(78.057±10.97)分,NPI苦恼因子分别为(30.532±5.82)和(34.208±6.50)分(P<0.05);治疗2周,治疗组与对照组NPI总分分别为(65.723±9.98)和(70.714±10.33)分,NPI苦恼因子分别为(29.177±6.52)和(32.567±7.44)分(P<0.05);治疗4周,治疗组与对照组BPRS评分分别为(30.277±6.43)和(35.01±7.38)分(P<0.05);治疗8周,治疗组与对照组NPI苦恼因子分别为(23.021±5.74)和(28.618±6.080)分(P<0.01)。治疗12周,治疗组和对照组MMSE分别为(7.83±3.02)和(7.116±2.67)分,较治疗前均有升高(P>0.05)。结论短期使用富马酸喹硫平治疗可降低AD照料者的苦恼,减轻AD患者精神行为症状,可能对认知功能产生有利影响。
Objective To study clinical application and safety of quetiapine fumarate in treating Alzheimer’s disease(AD).Methods A total of 74 patients with AD were randomly divided into treatment group(n=48)and control group(n=26).Patients in the control group were given 5 mg·d-1 of donepezil chloride,patients in the treatment group were given 5 mg·d-1 of donepezil chloride and 12.5 mg·d-1 of quetiapine fumarate.Before and 1,2,4,8 and 12 weeks after the treatment,the patients were evaluated by mini-mental state examination(MMSE),the brief psychiatric rating scale(BPRS),neuropsychiatric inventory(NPI),NPI distress factor and activity of daily life(ADL).Results After 1 week of treatment,total NPI score of treatment group and control group was(72.830±10.45)and(78.057±10.97),respectively;NPI distress factor was(30.532±5.82)and(34.208±6.50),respectively(all P<0.05).After 4 weeks of treatment,BPRS scores of treatment group and control group was(30.277±6.43)and(35.01±7.38),respectively(P<0.05).After 8 weeks of treatment,NPI distress factor of treatment group and control group was(23.021±5.74)and(28.618±6.08)(P<0.05).After 12 weeks,MMSE score of treatment group and control group was(7.83±3.02)and(7.116±2.67),which was increased compared with that before treatment(all P>0.05).Conclusion Short-term use of quetiapine fumarate can reduce anguish of AD tender,and relieve psychological and behavioral symptoms of AD patients,and may have positive effects on cognitive function.
作者
郭子雷
林勇
GUO Zilei;LIN Yong(Department of Geriatrics,Kangci Hospital of Jiaxing City,Zhejiang Province,Jiaxing 314500,China)
出处
《医药导报》
CAS
北大核心
2018年第10期1203-1206,共4页
Herald of Medicine
基金
浙江省医药卫生科技计划项目(2014KYB273)
关键词
喹硫平
富马酸
多奈哌齐
盐酸
阿尔茨海默病
精神行为症状
Quetiapine,fumarate
Donepezil,chloride
Alzheimer’s disease
Psychological and behavioral symptoms
作者简介
郭子雷(1983-),男,山东枣庄人,主治医师,硕士,研究方向:老年医学。E-mail:guozilei52@sina.com;通信作者,林勇(1980-),男,安徽人,副主任医师,硕士,研究方向:老年医学。E-mail:txly1980@163.com。
