摘要
目的探讨血清超敏C-反应蛋白(hs-CRP)与白蛋白(ALB)检查对早产儿早发感染的临床诊断意义。方法选取2015年2月-2016年3月于医院接受治疗的156例早产儿住院患儿为研究对象,根据早产儿感染状况分成感染组74例和未感染组82例。采集早产儿血液样本,检测早产儿白细胞计数(WBC)、血小板计数(PLT)及患儿进入新生儿重症监护病房24h的hs-CRP与ALB。结果本研究156例早产儿共出现感染74例,感染率47.44%,以肺炎为主。感染早产儿共检出90株病原菌,其中革兰阴性菌18株占20.00%,以大肠埃希菌为主,革兰阳性菌65株占72.22%,以金黄色葡萄球菌、表皮葡萄球菌为主。感染组白细胞计数、血小板计数、白蛋白分别为(13.28±4.20)×10~9/L、(238.30±41.02)×10~9/L、(26.54±10.25)g/L,均显著低于未感染组(17.10±5.12)×10~9/L、(261.05±42.06)×10~9/L、(29.64±12.24)g/L,而感染组24h和48hhs-CRP及ALB分别为(2.38±0.49)mg/L、(22.03±9.36)mg/L,且均显著高于未感染组(1.02±0.21)mg/L、(17.65±8.67)mg/L(P均<0.05),感染组48h之外死亡早产儿3例,死亡率4.05%。结论血清hs-CRP与ALB可作为早产儿早发感染的有效临床诊断指标,同时患儿进入新生儿重症监护病房24h内hs-CRP与ALB指标可较大提高诊断灵敏度。
OBJECTIVE To explore the clinical diagnostic values of serum high sensitivity C-reactive protein（hsCRP）and albumin（ALB）in premature infants with early infections.METHODS A total of 156 cases of premature infants hospitalized from Feb.2015 to Mar.2016 in our hospital for treatment were selected as the research objects,and were divided into infection group（74 cases）and non-infected group（82 cases）according to the infection status of premature infants.Blood samples of premature infants were collected for detection of white blood cell count（WBC）,platelet count（PLT）and hs-CRP and ALB at 24 hafter the infants admitted into the neonatal intensive care unit.RESULTS There were 74 cases of premature infants had infections in the 156 cases of patients,and the infection rate was 47.44%,which was mainly pneumonia.Totally 90 strains of pathogens were detected in infected premature infants,including 18 strains of gram-negative bacteria accounting for 20.00%,mainly Escherichia coli,and 65 strains of gram-positive bacteria accounting for 72.22%,mainly Staphylococcus aurous and Staphylococcus epidermises.The white blood cell count,platelet count and albumin of infection group were（13.28±4.20）×10~9/L,（238.30±41.02）×10~9/L and（26.54±10.25）g/L,which were lower than（17.10±5.12）×10~9/L,（261.05±42.06）×10~9/L and（29.64±12.24）g/L in non-infected group,and hs-CRP and ALB in infection group at 24 hand 48 hwere（2.38 ± 0.49）mg/L and（22.03 ± 9.36）mg/L,which were significantly higher than（1.02 ± 0.21）mg/L and（17.65± 8.67）mg/L in non-infected group（P〈0.05）.There were 3 cases died in infection group after 48 h,and the mortality rate was 4.05%.CONCLUSION Serum hs-CRP and ALB can be used as effective clinical diagnostic indexes of early infection in premature infants,and hs-CRP and ALB of infants within 24 hours of admission to the NICU can greatly improve the diagnostic sensitivity.
作者
王陈裕
何海雅
汤梦倩
杜姗
金燕芬
洪艳
胡荣全
WANG Chen-yu HE Hai-ya TANG Meng-qian DU Shan JIN Yan-fen HONG Yan HU Rong-quan(Fuyang Maternal and Child Health Care Hospital, Hangzhou, Zhejiang 311400, China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2017年第20期4772-4774,4786,共4页
Chinese Journal of Nosocomiology
关键词
超敏C-反应蛋白
白蛋白
早发感染
诊断效果
High sensitivity C-reactive protein
Albumin
Early infection
Diagnostic effect
