摘要
目的探讨血管内皮损伤生物标记物联合HbA1c、GA检测对妊娠糖尿病(GDM)的诊断价值。方法选取2013年2月至2014年2月来我院进行治疗的妊娠糖尿病患者120例为观察组,并选取同一时间来我院检查的健康孕妇60例为对照组。比较两组的基本生理生化指标,血管内皮损伤生物标记物包括血管内皮细胞粘附分子1(VCAM-1)、晚期氧化蛋白产物(AOPP),以及血清糖化血红蛋白(HbA1c)和糖化血清白蛋白(GA)水平。分析血管内皮损伤生物标记物和血清糖化血红蛋白及糖化血清白蛋白之间的相关性。结果观察组的TG、FBG、HbA1c、2hPG、GA、VCAM-1和AOPP水平均显著高于对照组(P<0.01)。血浆VCAM-1水平与FBG、HbA1c、2hPG和GA呈正相关,血浆AOPP水平与FBG、HbA1c、2hPG和GA呈正相关。结论 VCAM-1和AOPP与血糖相关检测指标HbA1c和GA水平之间存在着相关性,可通过检测血管内皮损伤生物标志物联合HbA1c和GA来对GDM进行诊断。
Objective To explore the diagnostic value of combined detection of HbA1c,GA and vascular endothelial injury biomarkers for gestational diabetes mellitus（GDM）. Methods 120 cases of GDM patients admitted to our hospital from February 2013 to February 2014 were selected as observation group,and 60 cases of healthy pregnant women in our hospital at the same period were selected as control group. The basic physiological and biochemical indicators,vascular cell adhesion molecule-1（VCAM-1）,advanced oxidation protein products（AOPP）,Hb Alc and glycated albumin（GA） were compared between two groups. The relationships of vascular endothelial injury biomarkers with HbA1c and GA were analyzed. Results The levels of TG,FBG,HbA1c,2h PG,GA,VCAM-1 and AOPP of observation group were significantly higher than those of control group（P〈0.01）. Plasma VCAM-1 level was positively related with FBG,HbA1c,2hPG and GA,and plasma AOPP level was positively related with FBG,HbA1c,2hPG and GA. Conclusions VCAM-1 and AOPP have relevance with blood glucose related indicators,suggesting that GDM can be diagnosed by combined detection of HbA1c and GA.
出处
《临床医学工程》
2017年第4期527-528,共2页
Clinical Medicine & Engineering
关键词
妊娠糖尿病
血管内皮损伤生物标记物
诊断价值
相关性
Gestational diabetes mellitus
Vascular endothelial injury biomarkers
Diagnostic value
Relevance
作者简介
朱天生（1975-），男，广东省博罗县人，大学本科学历，主管检验师．从事l临床医学检验工作。
