摘要
目的研究丁苯酞序贯治疗急性后循环梗死的有效性和安全性。方法将2013年1月至2015年6月住院治疗的急性后循环梗死患者120例随机分成丁苯酞治疗组56例和对照组55例。丁苯酞组第1~14天静脉滴注丁苯酞注射液每次25 mg,每日2次,第15~90天口服丁苯酞胶囊0.2 g/次,每日3次。应用NIHSS评分、Barthel指数、改良Rankin量表(mRS)对患者治疗后不同随访期进行神经功能、日常生活能力和预后评估。结果丁苯酞组14 d和90 d的NIHSS评分均较入组时降低(P〈0.05),对照组仅有90 d的NIHSS评分均较入组时降低(P〈0.05),丁苯酞组14 d和90 d的NIHSS评分均低于对照组(P〈0.05);丁苯酞组14 d和90 d的Barthel指数均高于对照组(P〈0.05);90 d随访丁苯酞组mRS评分低于对照组,预后良好率高于对照组(P〈0.05)。两组不良事件发生率差别无统计学意义(P〉0.05)。结论丁苯酞序贯治疗能够显著减轻后循环梗死患者神经功能障碍,提高日常生活能力,并改善预后。
Objective To assess the efficacy and safety of sequential treatment with dl-3-nbutylphthalide in patients with posterior circulation infarction. Methods One hundred and twenty hospitalized patients with posterior circulation infarction from January 2013 to March 2015 were randomly divided into dl-3-nbutylphthalide group( n = 56) and control group( n = 55). Dl-3-n-butylphthalide group was treated with venous dl-3-n-butylphthalide 25 mg / 100 ml each time,twice a day for 14 days,and then 0.2g oral,third per day from 15 days to 90 days. The degree of neurological deficit was compared through the National Institutes of Health Stroke Scale( NIHSS) score,the rehabilitation condition was compared through Barthel index,and modified Rankin Scale( mRS) score was compared between two groups before treatment and different follow-up phase after treatment respectively. Results In dl-3-n-butylphthalide group,the NIHSS score 14 days and 90 days were significantly lower than those before treatment,and were lower than those in control group( P〈0.05). The NIHSS score 90 days was lower than those before treatment in control group( P〈0.05). Dl-3-n-butylphthalide group was higher in Barthel index 14 days and 90 days than control group( P〈0.05). Dl-3-n-butylphthalide group was lower in mRS score 90 days and was higher in favorable prognosis rate than control group( P〈0.05). The rate of adverse events was similar between two groups( P〉0.05). Conclusions Sequential treatment with dl-3-n-butylphthalide can significantly reduce the neurologic disorder of patients with posterior circulation infarction,improve the ability of daily living and the prognosis.
作者
郑峥
陈艳
程琼
李永坤
汪银洲
Zheng Zheng(Department of Neurology, Fufian Provincial Hospital, F ufian Medical University Shengli Clinical College, Fuzhou 350001, China)
出处
《齐齐哈尔医学院学报》
2016年第22期2769-2771,共3页
Journal of Qiqihar Medical University
基金
2014年福建省立医院院内优秀青年课题项目(2014YNQN04)
关键词
后循环缺血
脑梗死
丁苯酞
预后
Posterior circulation ischemia
Cerebral infarction
Dl-3-n-butylphthalide
Prognosis
作者简介
通信作者:汪银洲,Email:wphd@163.com
