摘要
目的:研究运用母血清HCG、PAPP-A与超声颈项透明层厚度(NT)测量联合的一站式快速产前筛查体系(OSCAR)在海南地区染色体疾病及重度α地中海贫血(地贫)诊断中的应用价值。方法:对我院产前诊断中心的单胎妊娠病人进行11~13^(+6)周OSCAR产前筛查,对于唐氏及胎儿α重度地贫高风险者进行产前诊断。分析OSCAR对胎儿染色体病及重度α地贫的检出率及β-HCG、PAPP-A和NT的变化规律。结果:OSCAR唐筛阳性率5.6%,检出率90%;OSCAR中NT增厚时染色体异常风险增加、β-HCG升高、重度α地贫检出率为20%。结论:OSCAR系统对于海南地区的染色体疾病筛查有良好的应用价值,对于重度α地贫的诊断有辅助价值。
Objective：To study the value of combining serum HCG、PAPPA and ultrasound nuchal translucency thick-ness （NT）measurement at 1 1-14 weeks for （One-stop Clinic of Risk Assessment,OSCAR）in Hainan Province,for the pre-natal screen of chromosomal disorders and severe α-thalassemia.Methods：The patients at 1 1-13 ＋ 6 weeks in our hospital for prenatal examination were booked to make OSCAR prenatal screening,the patients at high risk of Down＇s and severe thalasse-mia received prenatal diagnosis for fetal karotype and thalassemia gene checking,pregnancy outcomes were followed-up.To an-alyze the detection rate of OSCAR in fetal chromosomal disease and its diagnostic value in fetal thalassemia.Results：1.The positive rate of OSCAR Down＇s screening was 5.6%,the detection rate was 90.0%.The incidence of chromosomal abnormali-ties and serumβ-HCG was increased when NT increased.The detection rate of severe alpha thalassemia with increasing NT was 20%.Conclusion：1.OSCAR Down＇s screening system for early pregnancy has high detection rate,and is noninvasive,afford-able and preferred prenatal screening method of Chromosome disease and it has partial value for severeα-thalassemia in Hainan province.
出处
《海南医学院学报》
CAS
2016年第15期1691-1693,1697,共4页
Journal of Hainan Medical University
基金
海南省重点科技计划项目(ZDXM20130063)
海南省科技计划项目(081006)~~
作者简介
凌奕（1968-），女，硕士，主任医师，电话：089866763236、13518883582，Email：dianalingyi@163．com。
[通讯作者]金松（1964-），男，主任医师，电话：089866763236、13322052966。
