摘要
目的探讨尼妥珠单抗联合同步放化疗治疗局部晚期食管癌患者的近期疗效。方法回顾性选择山东省日照市人民医院2012年1月至2013年1月收治的98例局部晚期食管癌患者,根据治疗方法不同分为单纯调强放疗组(29例)、同步放化疗组(44例)和尼妥珠单抗联合同步放化疗组(联合治疗组,25例)。观察并比较3组患者的近期疗效和不良反应发生情况。结果单纯调强放疗组、同步放化疗组、联合治疗组总有效率、1年生存率比较[69.0%(20/29)、81.8%(36/44)比92.0%(23/25);44.8%(13/29)、61.4%(27/44)比76.0%(19/25)],差异均有统计学意义(均P〈0.05)。3组患者放射性肺炎、放射性食管炎、血液学毒性(0~2级)发生率比较,差异均无统计学意义(均P〉0.05)。同步放化疗组、联合治疗组的血液学毒性(3—4级)发生率明显高于单纯调强放疗组[36.4%(16/44)、48.0%(12/25)比27.6%(8/29)],差异有统计学意义(P〈0.05),但联合治疗组与同步放化疗组比较差异无统计学意义(P〉0.05)。尼妥珠单抗急性不良反应轻微,出现恶心5例、皮疹3例、发热2例、血压下降1例,均未影响正常治疗。结论尼妥珠单抗联合同步放化疗治疗局部晚期食管癌疗效较好,患者耐受性较好。
Objective To evaluate the short-term effect of nimotuzumab combined with synchronal radio-chemotherapy in treating locally advanced esophageal carcinoma.Methods Ninty-eight patients with locally advanced esophageal cancer from January 2012 to January 2013 were enrolled and divided into intensity-modulated radiotherapy(IMRT)group(29 cases),synchronal radio-chemotherapy group(44 cases)and nimotuzumab combined with synchronal radio-chemotherapy group(combination group,25 cases).The short-term effect and adverse reactions were observed and compared among groups.Results The total effective rate and 1 year survival rate in IMRT group,synchronal radio-chemotherapy group and combination group were significantly different[69.0%(20/29)vs 81.8%(36/44)vs 92.0%(23/25),44.8%(13/29)vs 61.4%(27/44)vs 76.0%(19/25)~(P〈0.05).The incidences of radioactive pneumonia,radioactive esophagifis,and 0-2 grade hematology toxicity were not significantly different(P〉0.05).The incidence of 3-4 grade hematology toxicity in synchronal radio-chemotherapy group and combination group was significantly higher than that in IMRT group[36.4%(16/44),48.0%(12/25)vs 27.6%(8/29)1(P〈0.05),while no significant difference was found between synchronal radio-chemotherapy group and combination group(P〉0.05).In combination group,5 cases had nausea,3 cases had rashes,2 cases had fever and 1 case had blood pressure drop,the adverse reactions were mild and did not impact the therapy.Conclusion Nimotuzumab combined with synchronal radio-chemotherapy has good effect in treating locally advanced esophageal carcinoma,patients with well tolerance.
作者
费立升
孟令新
张桂芳
孟芹
徐美玲
丁兆军
Fei Lisheng;Meng Lingxin;Zhang Guifang;Meng Qin;Xu Meiing;Ding Zhaojun(Department of Oncology,Rizhao People's Hospital,Shandong Province,Rizhao 276826,China;Graduate School of Weifang Medical University)
出处
《中国医药》
2016年第6期844-847,共4页
China Medicine
基金
济宁医学院校级科研计划(JY2013KJ061)
关键词
食管肿瘤
尼妥珠单抗
疗效
不良反应
Esophageal cancer
Nimotuzumab
Efficiency
Adverse effects
作者简介
张桂芳,潍坊医学院研究生院肿瘤学在读硕士研究生;通信作者:孟令新,Email:menglx001623@163.com
