摘要
目的了解江苏省菌痢发病规律,分析菌型分布和药物敏感性特征,为菌痢防治提供科学依据。方法采用描述流行病学方法对2010-2012年江苏省菌痢监测资料进行分析,同时应用血清凝集和K-B纸片法进行血清分型和药物敏感性分析。结果2010-2012年江苏省菌痢年均发病率为8.49/10万,发病高峰是5-10月份,占3年总发病数的72.39%;在地区上呈散发态势,常州、镇江和徐州3市年均发病率最高;年龄分布以低年龄组为主,05岁组年均发病率最高。福氏志贺菌是优势菌群,其中F2a最多,占41.50%;宋内志贺菌变化显著。志贺菌对萘啶酸耐药率最高,其次为氨苄西林、四环素和复方新诺明。所有检测的抗生素中氨苄西林的耐药率增长最快。结论2010-2012年江苏省菌痢发病率较往年有所降低,志贺菌菌群比例变化显著,耐药及多重耐药现象日益严重。
Objective The study was conducted to assess the epidemic pattern of bacillary dysentery in Jiangsu Province and analyze the distribution and drug susceptibility of different types of bacteria, so to provide a scientific reference for the prevention and control of bacillary dysentery. Methods Descriptive epidemiological methods were adopted to analyze the monitoring results of bacillary dysentery in Jiangsu between 2010 and 2012, and serum agglutination and K-B methods were used for serotyping and drug susceptibility analysis. Results The average annual incidence of bacillary dysentery in Jiangsu between 2010-2012 was 8.49/100 000, with the epidemic peak occurred between May-October, accounting for 72.39% of the total incidence within the three years. The distribution of the incidence was sporadic, and Changzhou, Zhenjiang, and Xuzhou were the three cities with the highest annual average incidence. The majority of the incidence occurred among young age groups, with 0-5 age group having the highest annual average incidence. Shigella flexneri was the dominant bacteria, among which F2a was the most frequently occurring subtype （41.50%）; and Shigella sonnei had the most significant change over time. Shigella was most resistant against nalidixic acid, followed by ampicillin, tetracycline, and cotrimoxazole. Among all tested antibiotics, resistance against ampicillin had the most dramatic increase over the three years. Conclusion The incidence of bacillary dysentery in Jiangsu between 2010 and 2012 had a greater decrease than the previous years. However, the percentage of Shigella has changed significantly, and drug resistance and multi-drug resistance have become an increasingly serious issue.
出处
《现代预防医学》
CAS
北大核心
2014年第16期2886-2889,共4页
Modern Preventive Medicine
基金
江苏省"十二五"科教兴卫工程(ZX201109)
关键词
细菌性痢疾
发病率
血清分型
耐药性
Bacillary dysentery
Incidence
Serotyping
Drug resistance
作者简介
钱慧敏（1982．8-），女，硕士，主管技师，研究方向：传染病预防控制
通讯作者：汤奋扬，E-mail：ffyepi@163．com
