摘要
目的 :研究脂蛋白 (a) [L p(a) ]与绝经后女性冠心病 (CH D)的关系 ,并初步探讨内源性雌激素对血清 L p(a)水平的影响。方法 :采用 EL ISA法测定 5 2例绝经后女性 CHD患者及 48例健康者的血清 L p(a)浓度 ,并测定了其中 40例 CHD患者和 30例健康者的雌激素水平。结果 :CHD组平均 L p(a)浓度显著高于对照组 [(2 5 2 .9± 31.5 )∶ (12 9.2± 2 0 .0 ) mg/L ,P <0 .0 1],且与冠状动脉病变支数相关 ,r =0 .398,P <0 .0 0 1;而血清 L p(a)浓度与雌二醇水平未见显著关联。结论 :血清 L p(a)水平的增加是 CHD的独立危险因子 ,也是冠状动脉病变严重程度的一个预测因素 ,其浓度与内源性雌激素水平无关。
Objective:To evaluate the correlation between the Lp(a) concentration and coronary heart disease (CHD) in postmenopausal women, and to approach the effects of endogenous estrogen level on the serum Lp(a). Method:Serum Lp(a) concentrations were measured in 100 postmenopausal women with or without CHD by ELISA. Serum estradiol (E 2) level was determined in 70 women. Result:Women suffered from CHD had significant higher Lp(a) concentrations than controls [( 252.9 ± 31.5 )vs( 129.2 ± 20.0 )mg/L, P< 0.01 ]. Logistic regression analysis showed that the serum Lp(a) concentration was significantly correlated with CHD, and increase in serum Lp(a) was an independent risk factor (the adjusted OR is 4.54 , P< 0.01 ). Serum Lp(a) values had a grade association with the severity of CHD (the spearman rank correlation coefficient is 0.398 , P< 0.001 ). Whereas the serum E 2 had no correlation with Lp(a) concentration. Conclusion:Our result indicates that elevated Lp(a) is an independent risk factor for CHD in postmenopausal women, and is a predictor for the severity of CHD. The serum Lp(a) concentration does not correlated with the endogenous estrogen level.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2001年第5期211-213,共3页
Journal of Clinical Cardiology
关键词
脂蛋白类
绝经后
冠心病
CHD
Lipoprotein(a)
Postmenopausal
Coronary disease
