摘要
目的:探讨健步走和太极拳综合练习后非酒精性脂肪肝(NAFLD)患者肝损伤、储备功能及血脂的变化,分析有氧运动对NAFLD肝功能(肝损伤及储备功能)及血脂指标的影响差异。方法:随机抽取广州市番禺区自来水公司NAFLD患者24人(男性18人,女性6人),实施为期16周健步走和太极拳综合练习的有氧运动,每周4次,每次1小时。运动强度为60%～70%HRmax(HRmax=220-年龄),运动强度开始为50%～60%HRmax,逐步递增至60%～70%HRmax。分别于实验前和有氧运动16周后采用B超诊断受试者肝脏脂肪变性程度,测定受试者体重和BMI;于实验前、有氧运动8周后、16周后测定肝功能指标丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、谷氨酰转移酶(GGT)、碱性磷酸酶(ALP)、总蛋白(TP)、白蛋白(ALB)和血脂指标甘油三酯(TG)、胆固醇(TC)、载脂蛋白A-1(ApoA-1)、载脂蛋白B(ApoB)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。结果:(1)16周有氧运动后,B超结果显示,NAFLD患者肝脏改善平均有效率为70.8%,其中轻度脂肪肝较重度脂肪肝有效率显著升高(P<0.05)。受试者体重和BMI显著降低(P<0.05或P<0.01)。(2)与实验前比较,16周有氧运动后患者血清GGT、ALT、AST、ALP显著下降,TP、ALB和ALB/GLB显著升高,有氧运动8周后GGT、ALB出现显著变化(P<0.05或P<0.01)。(3)与实验前比较,8周有氧运动后LDL-C、载脂蛋白与脂质比值均出现显著变化(P<0.05或P<0.01)。结论:16周健步走和太极拳综合练习能有效改善NAFLD患者肝损伤、储备功能及血脂代谢紊乱,而GGT和ALB与其它肝功能指标相比较先变化。LDL-C、载脂蛋白与血脂脂质比值结合,较单一指标能更好地监控有氧运动改善NAFLD脂代谢紊乱过程。
Objective To discuss the effects of walking and Taijiquan practice on the hepatic injury and reserved function,and blood lipid of nonalcoholic fatty liver disease （NAFLD） sufferers. Methods Twenty four NAFLD sufferers（18 males and 6 females） were chosen randomly from Water Service Com- pany in Panyu District of Guangzhou City to carry out aerobic exercise （vigorous walk and Taijiquan Practice） one hour per day and four days per week for 16 weeks. Their exercise intensity started with50%-60%HRmax and then gradually reached 60%-70%HRmax （HRmax=220-age）. The hepatic steato sis of NAFLD sufferers was monitored by B ultrasound and their body weights and BMI were determined before and after 16-week aerobic exercise. Their liver function （ALT,AST,GGT,ALP） and blood lipid （TG, TC ,ApoA-l, and ApoB）were determined before exercise, 8 weeks and 16 weeks after exercise. Re- sults Hepatic steatosis of NAFLD sufferers after 16-week aerobic exercise were ameliorated,and the av- erage effective rate of the exercise was 70.$% significantly higher than that of severe NAFLD nificantly lower than before exercise （P 〈 0.05 centration of serum GGT,ALT,AST and ALP ,and the effective rate of exercise for mild NAFLD was （P 〈 0.05）. The average body weight and BMI were sig- and P 〈 0.01）. Compared with before exercise,the con- significantly decreased, while that GLB significantly increased after 16-week exercise,especially the concentration of TP,ALB and ALB/ of GGT and ALB im- proved soon after 8 weeks of exercise（P 〈 0.05 and P 〈 0.01 ）. Compared with before exercise,the value of LDL-C,apolipoprotein and the radios of blood lipids changed after 8 weeks of exercise （P 〈 0.05 and P 〈 0.01 ）. Conclusion The liver injury and lipid metabolic disorder of NAFLD sufferers can be amelio- rated through 16-week aerobic exercise by improving the hepatic reserved function. LDL-C and apolipoprotein lipid metabolic er with the radios of blood lipids are the best parameters for monitoring the blood disorder.
出处
《中国运动医学杂志》
CAS
CSCD
北大核心
2012年第12期1048-1053,1102,共7页
Chinese Journal of Sports Medicine
基金
广东省科技计划项目(2011B031600010)
关键词
有氧运动
非酒精性脂肪肝
肝功能
血脂
aerobic exercise, nonalcoholic fatty liver disease,liver function, blood lipid
作者简介
通信作者：肖国强。Email：xiaogqde@163．com
