摘要
目的 探讨层粘连蛋白 (LN)与Norplant致子宫不规则出血的关系。方法 对正常增殖期妇女子宫内膜 (6例 )和埋植Norplant半年、1年及 2年以上月经规律及有子宫不规则出血妇女 (各 6例 ,共 36例 )的子宫内膜进行组织学观察 ,并用显微分光光度计对用免疫组织化学方法显示的子宫内膜LN进行定量分析。结果 使用Norplant妇女的子宫内膜 ,(1)均无典型的周期特点 ,腺体明显减少 ,有腺体发育不同步现象 ;(2 )有不规则出血者腺上皮基膜和血管内皮基膜LN含量低于月经规律者 ,尤以埋植半年和 1年时明显 (P <0 .0 5 )。结论 Norplant致子宫异常出血与子宫内膜LN含量的减少有关。
Objective To investigate the relationship between endometrium laminin (LN)expression and irregular uterine bleeding in Norplant users. Methods Eighteen endomerium samples obtained during day 10～14th from Norlant users for 1/2, 1 or >2 years respectively with irregular bleeding were studied morphologically and immunohistochemically for LN expression. Six normal proliferative endometria and 18 connterpacts with regular bleeding were used as control. Results In Norplant users,endometrial glands decreased in numbers and asynchromized in appearance. The LN expression on basal lamina of glandular epithelium and vascular endothelium was lower in those with irregular bleeding as compared with regular bleeders ( P <0.05). Conclusion The decline of LN expression may related to irregular bleeding in Norplant users.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2000年第3期169-171,共3页
Chinese Journal of Obstetrics and Gynecology
基金
北京市自然科学基金资助(编号:7982015)
