摘要
目的研究阿托伐他汀对老年急性脑梗死患者颈动脉粥样硬化斑块及预后的影响。方法将120例老年急性脑梗死患者随机分为对照组与观察组,各60例。两组患者均给予阿司匹林、维生素E、维生素C等脑梗死常规治疗,观察组在对照组治疗基础上加用阿托伐他汀治疗,比较两组干预6个月后血脂水平、颈动脉粥样硬化斑块积分及日常生活能力。结果干预6个月后观察组血甘油三酯、总胆固醇及低密度脂蛋白水平显著低于对照组(P<0.01);观察组与对照组斑块积分分别为(3.78±0.68)分和(4.52±0.75)分,观察组显著低于对照组(P<0.01);改良Barthel指数评分分别为(77.90±21.74)分和(51.54±12.44)分,观察组显著优于对照组(P<0.01)。结论用阿托伐他汀治疗老年急性脑梗死患者,可显著降低血脂水平、减轻动脉粥样硬化程度,有助于患者日常生活能力的恢复。
Objective To explore the influence of atorvastatin on carotid atherosclerotic plaques and prognosis of aged acute cerebral in- farction. Methods 120 cases with aged acute cerebral infarction were randomly divided into the control group and the observation group with 60 cases in each group. The two groups were given the routine treatment such as aspirin, vitamin E and vitamin C. On this basis,the observation group was added atorvastatin. Blood fat,carotid atherosclerostic plaque scores and ability of daily life （ADL） after 6- month intervention were observed and compared between the two groups. Results Total triglyceride,total cholesterol and low density lipoprotein after 6- month intervention in the observation group were significantly lower than those in the control group（P 〈 0.01）. The plaque scores in the observation group and the control group were （3.78±0. 68） and （4.52 ±0.75）,respectively,the observation group was obviously lower than the control group （P 〈 0.01 ）. The scores of the modified Barthel index in the observation group and the con- trol group were （77.90±21.74） and （51.54±_12.44）,respectively,showing that the observation group was obviously superior to the control group（ P 〈 0. 01 ）. Conclusion Atorvastatin for treating aged acute cerebral infarction can greatly decrease the blood fat,alleviate the degree of arterial atherosclerosis and is benefit to the recovery of patient＇ s ADL.
出处
《中国药业》
CAS
2012年第20期25-26,共2页
China Pharmaceuticals
