摘要
目的:研究基质金属蛋白酶-2、-9(MMP-2、MMP-9)在实验组的表达及意义。方法:应用免疫组织化学SP法检测50例鼻腔鳞状细胞癌(实验组)和50例鼻腔正常组织(对照组)中MMP-2、MMP-9的表达,并分析其的表达与临床症状之间的关系。结果:①在实验组和对照组中的MMP-2阳性表达检出率分别为52%(26/50)和28%(14/50),差异有统计学意义(P<0.05);②在实验组和对照组中MMP-9阳性表达检出率分别为58%(29/50)和10%(5/50),差异有统计学意义(P<0.05)。结论:提示鼻腔鳞状细胞癌的发生、发展与MMP-2、MMP-9表达有关系。MMP-2、MMP-9在实验组的阳性表达率较高,对判断患者的预后有一定作用。
Objective：To study on the expression and significance of MMP-2 and MMP-9 in the nasus epithelial carcinoma and their signification.Method：Fifty cases of epithelial carcinoma tissue and 50 cases of normal nasus tissue were detected for MMP-2 and 9 by immunohistochemisry technique（SP）,and analysed their relationships between expression of MMP-and some clinical symptoms.Result：The positive ratio of expression of MMP-2 in 50 cases of epithelial carcinoma was 52.0%（26/50）,which was significantly higher than those in the normal nasus tissue 28.0%（14/50）,P0.05.The positive ratio of expression of MMP-9 in 50 cases of epithelial carcinoma was 58.0%（29/50）,which was significantly higher than those in the normal nasus tissue 10.0%（5/50）,P0.05.Conclusion：It was suggested that there was a close relationship between pathogenesis and development of nasus epithelial carcinoma and the expression of MMP-2,MMP-9 in the epithelial carcinoma tissues.The positive results of MMP-2,MMP-9 is partly valid for diagnosis of prognosis rate of MMP-2 and MMP-9 expression was high in nasus epithelial carcinoma tissues,MMP-2 and MMP-9 expression levels might be able to provide prognostic information.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2011年第22期1037-1039,共3页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
作者简介
通信作者：郑艳（Email：zy91900@sina．com）
