摘要
目的研究血管内皮生长因子(VEGF)与血小板活化因子受体(PAF-R)在正常早期妊娠及早期自然流产患者蜕膜及绒毛组织中的表达,探讨其与早期自然流产的相关性。方法选取2008年1月至2009年12月在我院妇产科就诊的60例患者作为研究对象,分为正常早孕人流组(A组)、先兆流产组(B组)、稽留流产组(C组)各20例;采用免疫组化技术对VEGF、PAF-R在三组蜕膜及绒毛组织中的表达进行组织学检查及定量分析。结果 (1)三组蜕膜及绒毛组织中VEGF、PAF-R均有阳性表达。(2)VEGF表达量:A组>B组>C组(P<0.05)。(3)PAF-R表达量:A组>B组>C组(P<0.05)。结论早期自然流产患者存在VEGF、PAF-R表达水平的降低,VEGF、PAF-R表达水平的改变可能是导致早期自然流产的重要原因。
Objective To investigate the expression levels of vascular endothelial growth factor （VEGF） and platelet activate factor receptor （PAF-R） in the decidua and villus of patients with normal early pregnancy and early spontaneous abortion,and to study the correlation between the expression of VEGF/PAF-R and early spontaneous abortion.Methods 60 patients admitted in the department of obstetrics and gynaecology in our hospital from January 2008 to December 2009 were assigned into three groups：group A （20 cases of induced abortion）,group B （20 cases of threatened abortion） and group C （20 cases of missed abortion）.Immunohistochemical techniques were used to investigate the expression levels of VEGF,PAF-R of histological in the three groups.Results Expressions of VEGF,PAF-R were found positive in decidua and villus tissue in all the three groups.The level of VEGF in group A is the highest,then follows group B and group C （P0.05）.The levels of PAF-R is highest in group A,and lowest in group C （P0.05）.Conclusion The expression level of VEGF and PAF-R were relatively low in patients with early spontaneous abortion,which might be an important factor that leads to early spontaneous abortion.
出处
《海南医学》
CAS
2011年第18期10-12,共3页
Hainan Medical Journal
基金
2010年度深圳市科技计划项目(编号:201003406)
2010年度深圳市龙岗区医疗卫生科技计划项目(编号:YLL2010010)
作者简介
徐俊（1977-），女，四川省宜宾市人，主治医师，学士。
