摘要
目的通过检测早期肾综合征出血热(HFRS)患者血浆中的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fib)、D-二聚体(D-dimer)和血小板(PLT),分析HFRS患者凝血功能变化及临床意义。方法实验组和对照组所有受试者凝血功能测定前均未进行过止血、抗凝和溶栓治疗。结果实验组D-dimer高于对照组,D-dimer与病情程度呈正比例关系,各组间差异有统计学意义(P<0.01)。实验组中PLT和Fib降低,差异有统计学意义(P<0.01);PT和APTT延长,差异有统计学意义(P<0.05)。PLT和Fib与病情程度呈反比例关系,各组间差异有统计学意义(P<0.01);PT和APTT与病情程度呈正比例关系,各组间差异有统计学意义(P<0.05)。DIC发病率与病情程度成正比,总死亡率4.6%。结论早期HFRS凝血功能检测,可以预示病情的严重程度,对DIC高危患者具有极高的预报价值。
Objective To detect early indicators of HFRS HFRS patients with blood coagulation and its clinical significance.Methods of experimental and control group,all subjects were measured coagulation were not carried out before the bleeding,anticoagulant and thrombolytic therapy.Results The D-dimer was higher in the experimental group and the Fib lower PLT,PT and APTT prolongation was statistically significant（P 〈0.05）.Incidence and severity of DIC was proportional to the total mortality rate of 4.6%.Conclusion Early detection of HFRS coagulation,can predict the severity of the disease,patients at high risk of DIC has a very high predictive value.
出处
《中国实用医药》
2011年第11期26-27,共2页
China Practical Medicine
