摘要
用甲硝基亚硝胍加酒精建立大鼠慢性萎缩性胃炎模型, 观察养胃冲剂对其胃粘膜组织病理学、前列腺素 E2 ( P G E2) 、生长抑素 ( S S) 、血浆胃动素 ( M O T) 的影响。结果造模大鼠经治疗胃粘膜光镜下 组织学明显改变, P G E2 、 S S 水平升高, 与造模组对比, 有显著性 差异 ( P< 0 .05) ; 血 浆 M O T 浓度 无显著 性差异 ( P> 0 .05) 。说明养胃冲剂可调节胃肠道激素分泌, 起到保护胃粘膜、修复损伤胃粘膜的治疗作用。
Setting up rat model of chronic atrophic gastritis(CAG) by using Methylnitronitrosoguanidine(MNNG) and alcohol,to observe the effect of Yangwei Granule(YWG)on gastric mucosa,prostaglandin E 2(PGE 2),somatostatin(SS) and plasma Motilin(MOT).Results:YWG could alter the structure of gastric mucosa,increase the level of PGE 2 and SS as compared with the control group ,the difference being significant (P< 0.05), while that of MOT was not significant(P> 0.05). Conclusion:YWG can protect the gastric mucosa and repair its damage by regulating the secretion of gastrointestinal hormone.
出处
《中药新药与临床药理》
CAS
CSCD
1999年第5期273-275,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
养胃冲剂
药理学
萎缩性胃炎
中医药疗法
Yangwei Granule/pharmacol.
Gastritis
atrophic/TCD ther.
Animal disease model