摘要
目的探讨生脉注射液防治急性心肌梗死患者介入术后再灌注损伤的疗效。方法采用随机对照试验方法 ,将62例急诊介入诊疗的急性ST段抬高心肌梗死患者随机分为2组:对照组应用常规治疗,治疗组在常规治疗基础上加用生脉注射液治疗,疗程7 d。观察2组再灌注损伤事件(再灌注心律失常、血管无再流或慢再流、心功能不全以及严重心血管事件)发生情况及临床疗效。结果与对照组相比,治疗组术后12 h内心律失常的发生率明显降低(P<0.05),左室射血分数显著升高(P<0.05),术后及酶峰cTnI、CK-MB明显减少。2组间严重心血管事件发生情况无显著性差异。2组均未见严重不良反应。结论生脉注射液防治急性心肌梗死介入术后再灌注损伤有一定的疗效。
Objective It is to explore the curative effect of Shengmai injection on reperfusion injury in patients with acute myocardial infarction（AMI）after PCI.Methods 62 cases of AMI patients with ST segment rising who were treated with emergency PCI were randomly divided into two groups through random-control method.The control group was given normal treatment,and the treatment group was added with Shengmai injection on the basis of treatment above.Both the treatment courses were 7 days.Reperfusion injury events（reperfusion arrhythmia,vascular no-reflow or slow flow,cardiac dysfunction and serious cardiovascular events） and clinical effect were observed.Results Compared with control group,the occurring rate of arrhythmia in 12 h after operation was obviously lower（P0.05）,left ventricular ejection fraction was obviously higher（P0.05）,and the enzyme peak cTnI,CK-MB were significantly less in treatment group.There was no significant difference in occurring rate of serious cardiovascular events between the two groups,and no serious side effect was found.Conclusion Shengmai injection has a curative effect on reperfusion injury after AMI PCI.
出处
《现代中西医结合杂志》
CAS
2010年第28期3553-3554,3561,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
北京中医药大学科研基金资助课题(2006X02)
关键词
生脉注射液
急性心肌梗死
再灌注损伤
Shengmai injection
acute myocardial infarction
reperfusion injury
作者简介
王轩（1968-），男，副主任医师，主要从事心血管内科临床和介入治疗工作。
