摘要
目的探讨原发性双侧乳腺癌（Bilateral Pri mary Breast Cancer,BPBC）的预后及其相关影响因素。方法对新疆医科大学附属肿瘤医院1996年3月~2006年10月收治的54例BPBC患者的临床资料进行整理,并对患者进行随访观察,生存率采用Kaplan-Meier的方法计算,用Cox回归模型进行预后因素分析。结果 BPBC的5年累计生存率为57.9%,同时性原发性双侧乳腺癌（Synchronous BPBC,sBPBC）的生存率与异时性原发性双侧乳腺癌（Metachronous BPBC,mBPBC）的生存率相比差别无统计学意义（P〉0.05）。单因素分析显示第一侧肿瘤分期、第二侧肿瘤分期、第二侧肿瘤激素受体情况对生存的作用有统计学意义。多因素分析表明第二侧肿瘤分期、第二侧肿瘤激素受体情况是影响患者生存的重要预后因素。结论双侧原发性乳腺癌的预后与两侧肿瘤均有关,在治疗过程中要兼顾二者情况,以提高患者的生存率。
Objective To evaluate the outcome and prognostic analysis of bilateral primary breast cancer（BPBC）.Methods The clinical data of 54 patients with BPBC,in Affiliated Tumor Hospital,Xinjiang Medical University from March 1996 to December 2006 were collected and analyzed on prognostic factors.Calculation of survival rate were calculated by Kaplan-Meier,Cox regressive mode were used to analyze prognostic.Results 5-year Cumulative Survival rate of BPBC were 57.9%.The differences cumulative survival rate between sBPBC（Synchronous BPBC,sBPBC）and mBPBC＇s（Metachronous BPBC,mBPBC）was not significant（P0.05）.The stage of bilateral tumor and hormone receptor of the second tumor affected the survival of BPBC significantly.The results of multivariate analysis showed that the stage and hormone receptor of the second tumor were prognostic factors of bilateral primary breast cancer.Conclusion The prognosis of bilateral primary mammary cancer is decided by the bilateral tumor.In order to enhance the survival Rate of bilateral primary breast cancer,we should think about the two sides of the tumor in therapy.
出处
《新疆医科大学学报》
CAS
2010年第6期656-659,共4页
Journal of Xinjiang Medical University
基金
乌鲁木齐市科学技术局支持项目(Y08231006)
关键词
双侧原发性乳腺癌
预后分析
生存率
bilateral primary breast cancer
prognostic analysis
survival rate
作者简介
李涌涛（1976-）．男，硕士研究生，主治医师．研究方向：乳腺肿瘤的诊治。
通讯作者：倪多．女，教授．主任医师．博士生导师．Email：lyt1822@126．com。
