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铜绿假单胞菌群体感应抑制剂研究进展 被引量：4

Research progress of Pseudomonas aeruginosa quorum sensing inhibitors
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摘要 铜绿假单胞菌是一种常见的机会致病菌,可在人群中引起严重的急性和慢性感染,是病人在医院期间发生感染的第三大致病菌。铜绿假单胞菌多种毒力因子的分泌以及生物被膜的形成都是受一种被称为群体感应(Quorum Sensing,QS)的胞间信号传导系统调控的。QS使细菌能够根据细胞密度变化进行基因表达的调控。通过抑制QS来治疗铜绿假单胞菌感染是一个很有前景的发展方向。本文将就近年来铜绿假单胞菌群体感应抑制剂的研究进展进行综述。 Pseudomonas aeruginosa is an increasingly prevalent opportunistic human pathogen that causes a wide range of acute and chronic infections and is the 3rd most common pathogen found in nosocomial and lifethreatening infections of immunocompromised patients. The production of virulence factors and biofilm development in this organism are all regulated by a microbial cell □ cell signaling system which was known as ＂quorum sensing＂ （QS）. QS controls the expression of gene in a population density-dependent manner.Therefore, inhibition of QS may provide alternative therapeutic methods for treating Pseudomonas aeruginosa infections. A number of studies aiming to control Pseudomonas aeruginosa virulence via disruption of QS signaling have been conducted.
作者 邹姗姗 宫倩红 尹守亮 于文功
机构地区 中国海洋大学医药学院海洋药物教育部重点实验室
出处 《现代生物医学进展》 CAS 2010年第5期949-953,共5页 Progress in Modern Biomedicine
基金 国家高技术研究发展计划项目(863项目)(2007AA09Z418)
关键词 铜绿假单胞菌 群体感应 抑制剂 Pseudomonas aeruginosa Quorum sensing Inhibitors
分类号 Q93 [生物学—微生物学]
作者简介 邹姗姗（1984-），女，硕士研究生，主要研究方向：铜绿假单胞菌群体感应电话：0532-82031562，E—mail：zoushanshan@126．com 通讯作者：于文功，E—mail：yuwg66@ouc．edu．cn
  • 相关文献

参考文献30

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二级参考文献30

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共引文献16

同被引文献39

  • 1薛秀园,张慧雯,涂国全.细菌对红谷霉素的耐药性检测[J].江西农业大学学报,2006,28(6):927-932. 被引量：3
  • 2王瑶,戴岳,张勇,胡杨波,杨宝玉,陈士云.群体感应信号分子降解基因对铜绿假单胞菌毒力和生物膜形成的影响[J].中国科学（C辑）,2007,37(2):234-240. 被引量：17
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引证文献4

二级引证文献15

现代生物医学进展
2010年 第5期

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