摘要
目的研究失匹配负波（mismatch negativity，MMN）波形提取的相关因素及刺激偏差对波形的影响，获得一套实验室标准值。方法以oddBall序列给予21名健康青年志愿者短纯音刺激，分为频率偏差刺激和强度偏差刺激两组，每组中又包含3个刺激系列，共6个小组。用偏差刺激引出的事件相关电位（event-related potential，ERP）减去标准刺激引出的ERP即得到MMN波形。记录各组潜伏期与波幅并两两比较，分析听刺激偏差程度对MMN的影响。结果本实验诱发出了健康青年人的MMN波形，并获得了潜伏期与波幅的正常值。频率偏差组中，频率差异为2kHz时的MMN潜伏期[（155．81±29．08）ms]与频率差异为1kHz时[（182．89±45．85）m8，（183．32-4-43．33）ms]相比，明显缩短（P值均〈0．05）；差异程度相同时，改变标准刺激与偏差刺激频率的绝对值，MMN潜伏期没有明显变化；各小组间MMN的波幅[（3．85±2．22）、（2．90±2．05）、（2．66±2．12）“V]差异无统计学意义（P值均〉0．05）。强度偏差组中，强度差异为20dB时MMN潜伏期[（157．04±34．87）ms]与强度差异为10dB时[（184．46±38．05）ms，（186．24±42．36）ms]相比，明显缩短（P值均〈0．05）；差异程度相同时，改变标准刺激与偏差刺激强度的绝对值，MMN潜伏期没有明显变化；其中只有组4和组6的MMN波幅[（3．41±1．64）μV，（2．37±1．47）μV]差异有统计学意义（P〈0．05），其余各组的波幅差异均无统计学意义。结论MMN只与刺激差异程度有关，与受试者的注意无关，属于认知功能的产物，能够客观地反映大脑探测刺激特征变化的能力。
Objective To work out the elicitation plan, obtain the mismatch negativity（MMN） and get out the laboratory normal value as well as to study the influence to MMN from the deviation of auditory stimuli. Methods Hearing test of the tone burst stimulation was performed on 21 healthy young volunteers according to oddball stimulation sequence. Each subject was performed two kinds of auditory stimuli including frequency deviant stimuli and intensity deviant stimuli, and of each one included three series of stimulation. MMN was gained by subtracting the ERP of deviant stimuli from the ERP of standard stimuli. The latency and amplitude of each MMN were recorded, and then the effect of the deviant extent for MMN was analyzed. Results By this setup the MMN of normal young people was recorded and normal value of latency and amplitude of MMN were got. In the group of frequency deviant stimuli, the MMN latency [ （155.81±29.08）ms] , if the frequency was up to 2000 Hz, was shorter than that when the frequency deviance was 1000 Hz [ （ 182.89 ± 45.85 ） ms, （ 183.32 ± 43.33 ） ms ] （ P = 0. 033, 0. 030） ; when the deviant extent were the same, the latency had no obvious difference if changing the frequency of the standard and deviant stimuli （ P = 0.973 ） ; the MMN amplitude of three groups [ （ 3.85 ± 2.22 ） μN, （ 2.90 ± 2.05 ） μN, （2.66 ± 2.12） μV] had no obvious difference among them （P 〉 0.05）. In the group of intensity deviant stimuli, the MMN latency [ （ 157.04 ± 34.87 ） ms ], if the frequency was up to 20 dB, was shorter （ P = 0. 025, 0.017） than that when the intensity deviance was 10 dB [ （ 184.46 ± 38.05 ） ms, （ 186.24 ± 42. 36） ms ]. When the deviant extent were the same, the latency had no obvious difference （ P = 0. 882 ） if changing the intensity of the standard and deviant stimuli but only group 4 and group 6 [ （3.41 ± 1.64） μV, （ 2.37 ± 1.47 ） μV ] were different in evidence （ P = 0.031 ） while the others had no obvious difference （ P = 0. 524, 0. 122 ）. Conclusions MMN was only related to the difference between standard stimuli and deviant stimuli, but there was no relationship between MMN and the notice, which indicate that MMN could objectively reflect the capability of brain to detect the change of stimuli. MMN is the representation of brain high-level sensory function.
出处
《中华耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2009年第3期182-187,共6页
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
关键词
诱发电位
听觉
反应时间
声刺激
Evoked potentials
Auditory perception
Reaction time
Acoustic stimulation
作者简介
通信作者：王宁宇，Email：wny@sohu．com
