摘要
目的:观察老年2型糖尿病患者(≥60岁)使用二甲双胍前后血乳酸水平的变化。方法:对1996年1月￣2006年12月在我院住院、使用二甲双胍并且进行血乳酸监测的122例老年糖尿病患者进行回顾性分析,观察二甲双胍治疗前后血糖、肝肾功能、血乳酸等指标的变化。结果:二甲双胍能有效降低老年糖尿病患者的空腹及餐后血糖水平,治疗前后肝肾功能无改变,血乳酸水平80.5%在正常范围内,无乳酸酸中毒的发生。按年龄分组,各组间血乳酸值无显著差异。按二甲双胍的用药剂量分组,总量在1500mg/d以下的不同剂量组血乳酸值也无显著差异。无论是否有肌酐清除率的下降,以及虽合并心肺疾病但无明显缺氧状态,均未引起体内乳酸水平的增高。结论:老年糖尿病患者应用二甲双胍治疗较为安全,但在一些风险人群使用二甲双胍应监测血乳酸水平。
Objective：To evaluate the changes of blood lactic acid level in ageing type 2 diabetes mellitus （T2DM） with metformin treatment.Methods：One hundred and twenty two cases of elderly patients with T2DM in our department were included, the changes of fasting blood glucose（FBG）, post blood glucose （PBG）, HbAlc,liver and renal function and blood lactic acid were evaluated before and after treatment.Results：The levels of FBG, PBG, HbAlc were significantly reduced after treatment respectively.The liver and renal function had no significantly change after treatment.No lactate acidosis happened in all the 122 elderly patients, 80.5% of blood lactic acid levels were within the normal range, the decline of creatinine clearance rate, complication of heart and lung disease didn＇t make an elevation of the blood lactic acid level, different doses below 1500 mg daily had no significant differences in the blood lactic acid level.Conclusion：Mefformin is safe in the treatment of elderly patient with T2DM.The patient with high risk of lactate acidosis should be monitored the blood lactic acid level during treatment.
出处
《中国药物应用与监测》
CAS
2008年第2期12-15,共4页
Chinese Journal of Drug Application and Monitoring
关键词
2型糖尿病
二甲双胍
老年
乳酸
Type 2 diabetes mellitus
Mefformin
Senility
Lactic acid
作者简介
杨光，女，在读硕士研究生，研究方向：老年糖尿病及其并发症的防治。
通讯作者：李春霖，女，主要从事老年内分泌与代谢方面的研究。E-mail：lcl301@yahoo．com．cn
