摘要
VE聚乙二醇琥珀酸酯(TPGS)是由VE琥珀酸酯与聚乙二醇酯化反应而得,它既含有VE亲脂基团,又含有聚乙二醇长链的亲水基团,是一种非离子型表面活性剂。可用作增溶剂、乳化剂、吸收增强剂、水溶性VE的原料等,以提高药物的生物利用度、提高水溶性差的药物的溶解性和作为药物释放系统、抗癌药的载体等。还介绍了TPGS的国内外合成及检测方法,我们合成的粗产品采用薄层色谱定性检测。
Tocopherol Polyethylene Glycol Succinate is prepared by the esterification of the acid group of d-atocopheryl succinate by polyethylene glycol. Its chemical structure contains both a lipophilic and a hydrophilic moiety, making it similar to a non-oin surface-active agent. TPGS can be used as a solubilizer, an emulsifier, an absorption enhancer and a water-soluble source of vitamin E. TPGS can enhance the bioavailablility of drugs, improve the solubility of the poor water soluble drugs, use as a vehicle of drug delivery systems and anticancer drugs. The item introduces the synthesis and analysis methods in aboard. The crude products of our synthesis can be analysed by TLC.
出处
《食品科技》
CAS
北大核心
2006年第10期159-161,共3页
Food Science and Technology
关键词
VE聚乙二醇琥珀酸酯
VE琥珀酸酯
应用
合成方法
tocopherol polyethylene glycol succinate（TPGS）
vitamin E succinate（VES）
application
synthesis
作者简介
王艳（1980-）,女,硕士研究生,主要从事VE衍生物合成的研究工作.
