摘要
目的 探讨介入性栓塞化疗加放疗对恶性骨肿瘤的治疗价值。方法44例恶性骨肿瘤患者随机分为两组：观察组29例（A组），主要行介入性栓塞化疗及放疗。治疗时先以碘油抗癌药乳剂、聚乙烯醇（PVA）微粒、明胶海绵粒／条或不锈钢圈栓塞肿瘤血管，然后行规范性放射治疗。对照组15例（B组），仅行放射治疗及全身静脉化疗。全部患者随访6～36个月。结果A组患者临床症状好转，X线随访肿块缩小，其中6例患者得到手术完整切除，患者6个月、12个月、36个月病灶进展复发率为3．5％、13．8％、51．7％，生存率分别为100．0％、93．1％、48。3％，其结果与B组对比差异有统计学意义（P〈0．05）。A组患者远处转移率高于B组，但经统计学处理差异无统计学意义。结论介入性栓塞化疗加放疗治疗恶性骨肿瘤，能获得较放化疗患者症状缓解及生存率较高、局部进展复发率较低的效果，是治疗恶性骨肿瘤的较好方法。
Objective To study the clinical value of treatment for malignant bone tuners by interventional chemoembolization combined radiotherapy. Methods Forty-four patients with malignant bone tumors were divided into two groups. In the study group（group A）, 29 cases were treated by infusion of lipiodol with chemotherapeutic drugs, and the tumor feeding arteries were embolized with PVA partials and Gelatin sponge or steel coils, then regional radiotherapy were administered regularly. In the control group（group B）, 15 cases received radiotherapy and systemic chemotherapy. All the cases were followed up for 6 to 36 months. Results Marked improvement of the symptoms and tumors decreased in size and volume in patients of group A was noticed. Six of them were operated successfully. The 6- ,12- ,36- month local control rates in group A were 3.5%, 13.8% and 51.7%. and the 6-, 12-, 36- month survival rates were 100.0 %, 93.1% and 48.3 %. The difference of local control rates and the difference of survival rates between the two groups were significant（P 〈 0.05）. Conclusion Interventional chemoembolization combined radiotherapy is an effective therapy for some malignant bone tumors with its lower local recurrence rate and its higher survival rate. It should be considered as a better method in treating malignant bone tumors.
出处
《中国医师进修杂志》
2006年第5期18-20,共3页
Chinese Journal of Postgraduates of Medicine
关键词
骨肿瘤
放射学
介入性
放射疗法
Bone tumor
Radiolcgy
Interventional
Radiotherapy
